Clinical and hemodynamic performance of the Mosaic bioprosthesis were very satisfactory during the first 6 years after clinical introduction.

We have developed a rat CPB with mild hypothermic cardioplegic arrest. This rodent model is suitable to study clinically relevant problems related to CPB,myocardial protection and systemic inflammation.

The 30-day lethality was 1.6% in the BIMA group, 1.7% in the SIMA group in patients under 70, and 4.1% (BIMA) and 4.0% (SIMA) in patients over 70 (p = n.s.). A significantly higher blood loss was observed in the BIMA group (BIMA 979+/-708 ml, SIMA 790+/-575 ml, p<0.05). The rethoracotomy rate due to bleeding was significantly higher in patients with BIMA (4.1%) compared to those with SIMA (2.5%, p<0.05). In patients with a body mass index (BMI) of less than 27, no significant difference could be found (SIMA 2.8%, BIMA 3.4%, p = n. s.). Patients with a BMI >27 showed a significantly higher rethoracotomy rate (SIMA 2.2%, BIMA 4.9%). A higher incidence of sternal instabilities could be observed in the BIMA group (4.2%, p<0.05). Diabetes mellitus could not be identified as an independent risk factor for sternal complications (SIMA 2.9%, BIMA 5.0%, p = n. s.). COUCLUSION: CABG using both IMA's can be performed in nearly all patients as a routine method with good clinical results and low mortality. Bleeding in the BIMA group within 48 hours was increased. BMI >27 could be identified as a risk factor for sternal complications, but not diabetes mellitus or age over 70 years.

The question of how long a flap depends on its pedicle cannot be answered clearly from the available literature. To address this, we investigated the time to flap autonomization in the wound bed and the length of time to the point when flap necrosis is reduced to a clinically negligible level. The superficial epigastric flap was raised in 24 rats. After 3, 5, 7, or 10 days of wound healing, the pedicle was again exposed, ligated, and divided. Values of blood flow (flow), velocity (velocity), hemoglobin level (Hb), and oxygen saturation (SO(2) ) were noninvasively measured using Laser spectrophotometry. The area of necrosis of the flap was 62.77 ± 1.71% after 3 days, 16.26 ± 0.86% after 5 days, 2.88 ± 0.14% after 7 days, and 1.64 ± 0.16% after 10 days (P < 0.001). Hb, flow, and velocity were found to be significant factors on developing flap necrosis at the preoperative and postoperative time point (P < 0.0001), whereas SO(2) and flow were significant predictors of necrosis at the time of pedicle ligation (P < 0.0001). The percentage changes of SO(2) (P < 0.0001), flow (P < 0.0001), and velocity (P = 0.001) between the different time points were significant predictors of flap necrosis. The time needed for the complete autonomization of vascularized free flaps in their wound beds has been found as completed between the 5th and 7th day postoperatively in this rat model. The area of flap necrosis depends on the present value of SO(2) , Hb, flow, and velocity at different time points, but, more importantly, also on the perioperative change of these parameters.