Objective: This study was undertaken to evaluate the effect of vestibular stimulation on motor coordination in Parkinson’s disease (PD) induced mice. Methods: 18 healthy adult male Swiss albino mice were used in this study. Vestibule was stimulated by caloric vestibular stimulation (CVS). Pesticide Rotenone was used to induce Parkinson’s disease (PD). Motor coordination was assessed by the fall-off time and the activity score using the rotarod and actophotometer, respectively. Results: In the rotarod test, there was a significant increase in the fall-off time (p<0.01) in the CVS PD group (131.63±18.34) on the 30th day when compared to the PD group (95.33±15.17). In the actophotometer, the activity score improved in the PD CVS group on the 15 (235±47.09) and 30th days (251.38±25.76), while there was no improvement in the PD group. This shows the significant effect of caloric vestibular stimulation on motor coordination in Parkinson’s disease. Conclusion: This study confirms that caloric vestibular stimulation with hot water resulted in the improvement of motor coordination in PD. Hence this study certainly merits further studies with a higher sample size to confirm the effect of caloric vestibular stimulation on the enhancement of motor coordination in individuals with Parkinson’s disease.

Objective: This prospective study was conducted to provide an authoritative database for beneficial effects of vestibular stimulation, a simple non-invasive method to alleviate the behavioral changes in Parkinson’s disease (PD). Methods: Vestibule is stimulated by caloric vestibular stimulation (CVS). Pesticide Rotenone is used to induce PD. Open field test and elevated plus maze were used to access learning, memory, and behavior. Results: Behavioral scores were taken before and after stimulation of the vestibular system. The scores were significantly different between rotenone-induced PD, control, and hot water vestibular stimulation groups (p<0.05). Conclusion: This study categorically confirms that CVS with hot water causes behavioral changes in PD. This study certainly merits further studies with higher sample sizes to confirm the effect of CVS for enhancement of learning, memory, and behavior in patients with Parkinsonism.