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Fine Needle Aspiration Cytology (FNAC) is a safe, reliable and cost effective tool that is used in the diagnosis of lesions in various organs. The diagnostic accuracy has significantly improved recently due to cytopathologists accumulating experience with this method and with the advent of diagnostic radiologic modalities. Many recent studies on FNAC for diagnosing neoplastic lesions with an epithelial origin and reactive lesions, including lymph nodes, indicate that it has a satisfactory diagnostic accuracy. 1 Soft tissue arises from the non-epithelial extra skeletal connective tissue exclusive of the reticuloendothelial system, glia and supporting tissue of various parenchymal organs. 2 ABSTRACT Background: Fine Needle Aspiration Cytology (FNAC) is a useful, safe and cost effective tool that is used in the diagnosis of lesions in various organs. Even though the literature on FNAC of soft tissue masses is relatively scarce, a large amount of interest has developed in this area in the last few years due to the low cost of the procedure, low incidence of complications, feasibility and high therapeutic efficiency. So the present study was undertaken to study the nature of various soft tissue tumors by FNAC and to compare the cytological diagnosis with the results obtained by biopsy. Methods: All cases 713 (Prospective-217 and Retrospective 496) included in present series were taken up for study. Aspiration of soft tissue lesions were performed following the technique of Zajicek et al. Smear was prepared, stained and examined. Histopathological details were available in 140 cases. Data was compiled in MS excel and checked for its completeness, correctness and then it was analyzed. Results: Total number of 11,560 FNAC was done in six and half year's period from 1 st April 2003 to 30 th September 2009. Out of the total 713 cases of soft tissue tumors, 71.25% were reported as benign and 28.75% as malignant. Soft tissue tumors were more common in males in comparison to females, with M: F-1.63:1. Accuracy of FNAC for benign and malignant soft tissue tumours was 88.1% and 92.9% respectively. Conclusion: The overall diagnostic accuracy of FNAC in the present study was found 90%. FNAC is a safe and reliable method of recognizing benign and malignant soft tissue tumors and in most instances histological sub typing is possible. Cytological diagnosis must be based on strict cytological criteria and well controlled ancillary techniques.

A intermediate (Aint) subtypes exhibit characteristics intermediate between A1 and A2. Plasma from Aint individuals contains different enzyme, UDP-GalNAc: fucosylgalactoside-a-3-N-acetylgalactosaminyl transferase, which is different from the enzyme in A1 and A2 plasma. We encountered the case of a 54-year-old female (having pneumonia and chronic kidney disease) for pre-transfusion testing. On routine grouping, we encountered group discrepancies. On testing, anti-A gave 4+, anti-B-0, anti-A1 lectin-2+, anti-H lectin, and anti-AB antisera gave 4+ reactions. Reverse grouping gave 4+ with B cells, 2+ at room temperature with A cells, and 4+ and 1+ at 37°C and 4°C. Saliva inhibition studies showed A and H substances. It was typed as an Aint group with warm anti-A1 antibody. It’s the 1st time ever we encountered Aint case with a warm type anti-A1 antibody. Here, O group packed red cells are the suitable blood units to transfuse.

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