Cobalt‐based bimetallic phosphide encapsulated in carbonized zeolitic imadazolate frameworks has been successfully synthesized and showed excellent activities toward both hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). Density functional theory calculation and electrochemical measurements reveal that the electrical conductivity and electrochemical activity are closely associated with the Co2P/CoP mixed phase behaviors upon Cu metal doping. This relationship is found to be the decisive factor for enhanced electrocatalytic performance. Moreover, the precise control of Cu content in Co‐host lattice effectively alters the Gibbs free energy for H* adsorption, which is favorable for facilitating reaction kinetics. Impressively, an optimized performance has been achieved with mild Cu doping in Cu0.3Co2.7P/nitrogen‐doped carbon (NC) which exhibits an ultralow overpotential of 0.19 V at 10 mA cm–2 and satisfying stability for OER. Cu0.3Co2.7P/NC also shows excellent HER activity, affording a current density of 10 mA cm–2 at a low overpotential of 0.22 V. In addition, a homemade electrolyzer with Cu0.3Co2.7P/NC paired electrodes shows 60% larger current density than Pt/RuO2 couple at 1.74 V, along with negligible catalytic deactivation after 50 h operation. The manipulation of electronic structure by controlled incorporation of second metal sheds light on understanding and synthesizing bimetallic transition metal phosphides for electrolysis‐based energy conversion.

In the conventional non-invasive cancer treatments, such as photodynamic therapy (PDT) and photothermal therapy (PTT), light irradiation is precisely focused on tumors to induce apoptosis via the generation of reactive oxygen species (ROS) or localized heating. However, overconsumption of oxygen and restricted diffusion distance of ROS limit the therapeutic effects on hypoxic tumors. Herein, we developed a platform for the rapid uptake of multifunctionalized Au@Pt nanoparticles (NPs) by mitochondria in cancer cells. The mesoporous Au@Pt nanoparticles were labeled with a cell-targeting ligand (folic acid), a mitochondria-targeting group (triphenylphosphine (TPP)), and a photosensitizer (Ce6). This led to significant improvement of the PDT efficacy due to an enhanced cellular uptake, an effective mitochondrial ROS burst, and a rapid intelligent release of oxygen. Moreover, Au@Pt NPs can convert laser radiation into heat, resulting in thermally induced cell damage. This nanosystem could be used as a dual-mode phototherapeutic agent for enhanced cancer therapy and molecular targets associated with disease progression. We achieved a mitochondria-targeted multifunctional therapy strategy (a combination of PDT and PTT) to substantially improve the therapeutic efficiency.

With a mild elaborately bioinspired one-pot process, Con A-GOx-CaHPO4 nanoflowers are prepared. Employing the as-prepared all-in-one hybrid nanoflowers as signal tags, a simple but potentially powerful amplification biosensing technology for the detection of food pathogen with excellent simplicity, portability, sensitivity, and adaptability is achieved.

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