A series of novel oxazole derivatives (A, A1, A2) were synthesized starting from acetone and urea. The compound (A) was obtained by heating it with acetophenone and urea in iodine. Compound (A) on treatment with 4-amino benzaldehyde (Z)-N-(4-amino benzylidine)-4-((E)-Penta-2, 4-diene-2) oxazole-2-amine afforded (A1). Acylation of compound (A) with 4-amino benzoyl chloride to obtain the corresponding N-(4 phenyl oxazole-2- yl)- benzamide (A2). The structures of compounds have been established employing FTIR and 1H-NMR spectral analysis. All oxazole derivatives were evaluated for anti-inflammatory activity by the carrageenan-induced Rat hind paw method. Derivative A1 shows maximum anti-inflammatory activity. Keywords: Oxazoles, anti-inflammatory, Benzamide, acetophenone, indomethacin.

Polycystic ovary syndrome (PCOS), also known as Stein-Leventhal Syndrome, was first described in 1935. PCOS, which may also be referred to as polycystic ovary disease is the most common hormonal disorder found in premenopausal women. PCOS is the most common endocrine disorder in women of reproductive age and is the most common cause of infertility due to ovulation. A PCOS is an endocrine disorder which affects the adolescent girls. A PCOS is a condition in which a woman has an imbalance of female sex hormones. This may lead to changes in the menstrual cycle, cyst in the ovary, failure to conceive, and other health problems. It is a common health problem among teenagers and young women. It affects 5–10% of women in their reproductive years. These problems cause infertility. Two principal components to diagnose this syndrome are menstrual dysfunction and clinical or laboratory hyperandrogenism in which these items are used in clinical diagnosis. PCOS is a hormonal disorder that affects between 5% and 10% of women of reproductive age and remains the most enigmatic reproductive disorders. The most common symptoms of PCOS are obesity, acne, amenorrhea, irregular menstrual cycles, hirsutism, insulin resistance (IR), and high cholesterol. Due to the varied nature of PCOS and the large range of possible signs and symptoms, health personnel need a thorough knowledge of the disorder and its management. It is a major disorder characterized by elevated levels of male hormones (androgens), acne, and hirsutism. It can even cause IR, anovulation, and infertility on prolonging incidence of cysts. One of the treatments for PCOS is the use of synthetic medicine, which can help to treat PCOS but with side effects. However, many women who suffer from PCOS opt to use alternative medicine in conjunction with traditional medicine to improve their condition. There are some herbs that are very helpful in treating PCOS. Since PCOS is a curable disorder, it can be cured by the use of natural remedies or allopathic medication. There is a growing interest in herbal remedies or allopathic medication to cure the PCOS. There is a need to change the lifestyle management, diet to control the PCOS level. The natural remedies include treatment with phytoestrogenic and non-estrogenic herbs such as Licorice, Ginseng, Black cohosh, Dong, soy, evening primrose, honey, fenugreek, Schisandra root, and many other which are effective and safe. Many plants have been highly esteemed sources and have advantages which reduce PCOS and also having a hypoglycemic effect. In this review, an attempt has been made to study the use of natural remedy for the treatment of PCOS.

Dispersible tablets are uncoated or film-coated tablets meant to be spread in water before administration giving a unvaried dispersion. Pediatric and old patients face complications in swallowing the conventional tablets. So according to the need dispersible tablets have been developed which combine the benefits of liquid dosage forms and solid dosage forms. The dispersible tablets allow dispersion in water prior to administration. In present study we have compared three brands of different dispersible tablets. The objective of the study was to find out the best dosage form based on the post compression parameters of dispersible tablets and to develop a co-relation among these parameters. Three brands of dispersible tablets had been selected i.e. Acetylsalicylic acid, Cefixime & Paracetamol tablets and they have been compared on the basis of different parameters of dispersible tablets like uniformity of weight, friability testing, hardness, wetting time, wetting volume, water absorption ratio, dispersion time, disintegration time, uniformity of dispersion. Acetylsalicylic acid & Cefixime complies all the parameters except friability test, while Paracetamol tablets complies all the tests except it was showing more hardness compared to other two brands due to which it’s properties like wetting time, wetting volume, water absorption ratio, dispersion time, disintegration time was lower than other two. So after overall comparison Cefixime was found to be the best in comparison to other two brands. Keywords: Dispersible tablets, paracetamol, cefixime, acetylsalicylic acid, comparison, post compression parameters.