An experimental study on a film cooled nozzle guide vane has been conducted in a transonic annular sector to observe the influence of suction and pressure side film cooling on aerodynamic performance. The investigated vane is a typical high pressure gas turbine vane, geometrically similar to a real engine component, operated at an exit reference Mach number of 0.89. The aerodynamic results using a five hole miniature probe are quantified and compared with the baseline case which is uncooled. Results lead to a conclusion that the aerodynamic loss is influenced substantially with the change of the cooling flow rate regardless the positions of the cooling rows. The aerodynamic loss is very sensitive to the blowing ratio and a value of blowing ratio higher than one leads to a considerable higher loss penalty. The suction side film cooling has larger influence on the aerodynamic loss compared to the pressure side film cooling. Pitch-averaged exit flow angles around midspan remain unaffected at moderate blowing ratio. The secondary loss decreases (greater decrease in the tip region compared to the hub region) with inserting cooling air for all cases compared to the uncooled case.

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Background and purpose: Mild cognitive impairment with Lewy bodies (MCI-LB) is associated with a range of cognitive, motor, neuropsychiatric, sleep, autonomic, and visual symptoms. We investigated the cumulative frequency of symptoms in a longitudinal cohort of MCI-LB compared with MCI due to Alzheimer disease (MCI-AD) and analysed the ability of a previously described 10-point symptom scale to differentiate MCI-LB and MCI-AD, in an independent cohort. Methods: Participants with probable MCI-LB (n = 70), MCI-AD (n = 51), and controls (n = 34) had a detailed clinical assessment and annual follow-up (mean duration = 1.7 years). The presence of a range of symptoms was ascertained using a modified version of the Lewy Body Disease Association Comprehensive LBD Symptom Checklist at baseline assessment and then annually.Results: MCI-LB participants experienced a greater mean number of symptoms (24.2, SD = 7.6) compared with MCI-AD (11.3, SD = 7.4) and controls (4.2, SD = 3.1; p < 0.001 for all comparisons). A range of cognitive, parkinsonian, neuropsychiatric, sleep, and autonomic symptoms were significantly more common in MCI-LB than MCI-AD, although when present, the time of onset was similar between the two groups. A previously defined 10-point symptom scale demonstrated very good discrimination between MCI-LB and MCI-AD (area under the receiver operating characteristic curve = 0.91, 95% confidence interval = 0.84-0.98), replicating our previous finding in a new cohort.

An experimental investigation on a cooled nozzle guide vane has been conducted in an annular sector to quantify aerodynamic influences of shower head and trailing edge cooling. The investigated vane is a typical high pressure gas turbine vane, geometrically similar to a real engine component, operated at a reference exit Mach number of 0.89. The investigations have been performed for various coolant-to-mainstream mass-flux ratios. New loss equations are derived and implemented regarding coolant aerodynamic losses. Results lead to a conclusion that both trailing edge cooling and shower head film cooling increase the aerodynamic loss compared to an uncooled case. In addition, the trailing edge cooling has higher aerodynamic loss compared to the shower head cooling. Secondary losses decrease with inserting shower head film cooling compared to the uncooled case. The trailing edge cooling appears to have less impact on the secondary loss compared to the shower head cooling. Area-averaged exit flow angles around midspan increase for the trailing edge cooling.