BACKGROUNDOrganophosphate insecticides/pesticides are used widely throughout the world. The organophosphorus poisoning is a very serious condition that needs rapid treatment. Emergent and appropriate management is always desirable to prevent the serious complications and high mortality. In this study, we determine the clinical presentation and outcome of organophosphorus poisoning in our institute.

A prospective case control study of lipid profile abnormalities in patients with subclinical hypothyroidism in J. L. N Hospital Ajmer. METHODS: 25 cases and 25 controls were included into the study. Cases had TSH> 5.0µIU/ml with normal T3 and T4 values. Controls were euthyroid patients. A detailed history, clinical examination, investigations like complete blood counts, fasting blood sugars, fasting thyroid profile and fasting lipid profile were done for all cases and controls. RESULTS: The mean TSH level in subclinical hypothyroidism cases (n=25) was 10.01±3.87miIU/L, when compared to euthyroid controls (n=25), it was 2.69±1.52 miIU/L. The mean LDL cholesterol level in subclinical hypothyroidism cases (n=25) was 93.9±16.6mg/dl, when compared to controls, it was 84.7±11.6mg/dl. CONCLUSION: The present study showed a higher prevalence of subclinical hypothyroidism among females of reproductive age group. significantly higher levels of total cholesterol, Triglyceride and VLDL cholesterol in patient with subclinical hypothyroidism, though elevation in LDL cholesterol level was found to be statistically significant, but it remained well within the upper limit of normal, hence it is clinically significant and there was no statistically significant relation found between HDL cholesterol and subclinical hypothyroidism.

Coronary Artery Disease (CAD) remains the major cause of mortality and morbidity of mankind. It is predicted that more than half the worldwide cardiovascular disease risk burden will be borne by Indian sub-continent in the next decade according to a recent epidemiological studies. 1 There is Significant differences in the prevalence of coronary artery disease exist with respect to gender, age and ethnicity. The introduction of coronary care units decreased Acute MI mortality from 30% to 15%; while the use of thrombolytics further decreased it to 5-7%. 2 Prompt reperfusion of the occluded artery through Percutaneous coronary angioplasty or thrombolytic therapy decreases the duration of occlusion leading to improved mortality. 3 In-hospital observation is warranted in patients at increased risk for sudden life threatening complications, such as late ventricular fibrillation, cardiac arrest or re-infarction. Present study is aimed at knowing clinical profile, early complications in AMI and causes for death.

BACKGROUND:Organophosphates exposures are a global health problem especially in India. Although extensive data is available regarding the pattern of OP poisoning in India, there is only little information regarding the victim profiles and the factors which influence mortality in southern India. The present study aimed to analyze the patterns, the social factors and the clinical outcomes of OP poisoning in this region. MATERIAL AND METHODS: This study carried out in Medicine department, SIMS, Shimoga from July 1st, 2014 to Dec. 31st, 2014. A total of 74 cases of OP poisoning were studied. The diagnosis of the OP compound poisoning is done by history, examination and pseudo cholinesterase level estimation. RESULT: Out of a total of 74cases of poisoning, 33 (44.59%) were males and 41 (55.40 %) were females. Most of the cases were from the rural areas (45 cases-60.81%). Incidence is highest in illiterate (48.64%), the total percentage of the married cases was 67.56%, the highest number of cases (33.78%) was from the age group of 21 to 30 years. The OP poisoning occurred mainly during night (55.40%) highest in summer season (27 cases), the mean hospital stay was 4.25 days, with a majority of the cases staying for 3 to 7 days in the hospital (52.70%). The mortality in the present study was 29.72% (22 cases). The commonest OP compound poison consumed is chlorphyriphos. CONCLUSION: organ phosphorus poisoning is a major health hazard in the community. It needs to be managed rapidly with upgradation of treatment at PHC level. These findings demand a swing in emphasis in community education towards hazardous of the poisoning and design appropriate health education programme to reduce both mortality and morbidity.