The European Radiobiology Archives (ERA), supported by the European Commission and the European Late Effect Project Group (EULEP), together with the US National Radiobiology Archives (NRA) and the Japanese Radiobiology Archives (JRA) have collected all information still available on long-term animal experiments, including some selected human studies. The archives consist of a database in Microsoft Access, a website, databases of references and information on the use of the database. At present, the archives contain a description of the exposure conditions, animal strains, etc. from approximately 350,000 individuals; data on survival and pathology are available from approximately 200,000 individuals. Care has been taken to render pathological diagnoses compatible among different studies and to allow the lumping of pathological diagnoses into more general classes. 'Forms' in Access with an underlying computer code facilitate the use of the database. This paper describes the structure and content of the archives and illustrates an example for a possible analysis of such data.
Animal experiments have contributed a great deal to our information on effects and risks arising from exposure to radionuclides. This applies, in particular, to alpha-emitting radionuclides where information from man is limited to thorotrast, 224Ra and 226Ra. The late C.W. Mays was the first to suggest that animal data in conjunction with epidemiological data could allow estimates of human risks for radionuclides - predominantly from actinides - where information in man is scarce. The 'International Radiobiology Archives of Long-term Animal Studies' were created through the combined efforts of European, American and Japanese scientists and aim to safeguard the large amount of existing data on long-term animal experiments and make them available for, among others, an improved assessment of risks from alpha-emitting radionuclides. This paper summarizes the structure of the archives and reviews their present status and future plans. It also demonstrates the extensive information available in these archives on alpha-emitting radionuclides which is suitable for further analysis. Also, the structure of the animal archives could - in a slightly modified form - accommodate the epidemiological data available on 224Ra and thorotrast and, thus, facilitate a direct comparison of data from man, dogs and rodents.
The European Radiobiology Archives (ERA) aims to collect most of the information still available in Europe on long-term animal experiments--including some selected human studies suitable for comparison with animal data--and to make them available to the scientific community for further analysis. ERA cooperates with the US (National Radiobiology Archives, NRA) and Japan (Japanese Radiobiology Archives, JRA) in the International Radiobiology Archives (IRA).
For the construction of the longest rail tunnel in the world, the selection of the optimal method of tunnelling was of considerable importance. Not only the ground properties were decisive for the decision but also other constraints, like for example the environmental requirements or the access to intermediate starting points. In two of the five sections, the employer had essential grounds for the specification of tunnelling method, but in three of the five sections, there were no essential grounds in the view of the employer. The selection of tunnelling method was therefore decided by economic criteria as the result of competition between the international bidders in the tendering phase. In the end, TBMs were used in all three sections. Für den Bau des derzeit längsten Eisenbahntunnels der Welt war die Auswahl der optimalen Vortriebsmethode für den Projekterfolg von entscheidender Bedeutung. Nicht nur die Baugrundeigenschaften waren maßgebend für die Wahl, sondern viele andere Randbedingungen auch, z.B. die Anforderungen aus dem Umweltschutz oder aber die Zugänglichkeit zu Zwischenangriffen. Bei zwei von fünf Abschnitten hatte der Bauherr zwingende Gründe, die Vortriebsmethode vorzugeben. Bei drei von fünf Abschnitten fehlten aus Bauherrensicht zwingende Vorgaben. Die Wahl der Vortriebsmethode erfolgte deshalb aufgrund wirtschaftlicher Kriterien als Resultat des Wettbewerbes unter den internationalen Anbietern in der Angebotsphase. In allen drei Abschnitten kam schließlich der TBM‐Vortrieb zum Einsatz.
The provisions of the planning approval for the Gotthard Base Tunnel required more than 1, 000 environmental measures for the Amsteg and Erstfeld sections, arranged in 80 detail projects. The environmental aspect was also of great significance for the client. Therefore AlpTransit Gotthard AG provided sufficient resources to be able to implement the project successfully from the environmental point of view. The article is concentrated on selected aspects and explains their special features. The integration of environmental monitoring into the local construction supervision team; soil protection and cultivation; the problem of nitrite in the site wastewater; and dust and noise emissions are dealt with in detail, along with the ecological opportunities of a large construction site. A description of the usual conditions and measures affecting a tunnel site is intentionally omitted. Die Plangenehmigungsverfügungen zum Gotthard‐Basistunnel sahen für die Teilabschnitte Amsteg und Erstfeld mehr als 1.000 Umweltmaßnahmen vor, die in 80 Detailprojekten eingeordnet waren. Der Umweltaspekt war auch für die Bauherrschaft von hoher Bedeutung. Daher setzte die AlpTransit Gotthard AG genügend Ressourcen zur Verfügung, um das Projekt auch aus Umweltsicht erfolgreich umsetzen zu können. Der Beitrag konzentriert sich auf ausgewählte Aspekte und zeigt deren Besonderheiten auf. Im Einzelnen werden die Integration der Umweltbaubegleitung in die örtliche Bauleitung, der Bodenschutz und die Rekultivierung, die Nitritproblematik im Baustellenabwasser, Staub‐ und Lärmemissionen sowie die ökologische Chancen einer Großbaustelle behandelt. Auf eine Darstellung der üblichen Auflagen und Maßnahmen bei einer Tunnelbaustelle wird bewusst verzichtet.
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