No abstract

In the present scenario, the SARS-CoV-2 virus has imposed enormous damage on human survival and the global financial system. It has been estimated that around 111 million people all around the world have been infected, and about 2.47 million people died due to this pandemic. The major symptoms were sneezing, coughing, cold, difficulty breathing, pneumonia, and multi-organ failure associated 1with SARS-CoV-2. Currently, two key problems, namely insufficient attempts to develop drugs against SARSCoV-2 and the lack of any biological regulating process, are mostly responsible for the havoc caused by this virus. Henceforth, developing a few novel drugs is urgently required to cure this pandemic. It has been noticed that the pathogenesis of COVID-19 is caused by two main events: infection and immune deficiency, that occur during the pathological process. Antiviral medication can treat both the virus and the host cells. Therefore, in the present review, the major approaches for the treatment have been divided into "target virus" and "target host" groups. These two mechanisms primarily rely on drug repositioning, novel approaches, and possible targets. Initially, we discussed the traditional drugs per the physicians' recommendations. Moreover, such therapeutics have no potential to fight against COVID-19. After that, detailed investigation and analysis were conducted to find some novel vaccines and monoclonal antibodies and conduct a few clinical trials to check their effectiveness against SARSCoV-2 and mutant strains. Additionally, this study presents the most successful methods for its treatment, including combinatorial therapy. Nanotechnology was studied to build efficient nanocarriers to overcome the traditional constraints of antiviral and biological therapies.

The term "hydrocarbon" is self-explanatory and refers to solely carbon and hydrogen compounds. Hydrocarbons play an important role in our everyday lives. Hydrocarbons, particularly polycyclic aromatic hydrocarbons, harm biota. The relatively fast introduction of xenobiotic compounds, as well as the enormous movement of natural materials to various environmental compartments, can often overwhelm the self-cleaning capabilities of the recipient ecosystem, resulting in pollution and accumulation of hazardous or even lethal levels. Bacteria capable of hydrocarbon degradation are frequently used in the bioremediation of fuel oil-contaminated sites. Presently, multiple sophisticated methodologies, transcriptomics, proteomics and are effectively utilized for the depiction of hydrocarbons degrading microorganisms. These expertises are highly developed, and its integration with bioinformatics tools makes it even more efficient. Though health science and biological science are the major relevant areas for molecular docking, it has been effectively used to explore the process of bio-degradation in ecological remediation in recent years. This review focuses on the sources, fate of PAHs, human exposure, various computational aspects associated with PAHs, and some approaches of synthetic biology related to pollutant degradation and PAH‑degradation by genetically engineered microorganisms.