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The article deals with the problems of formal description of methods of organization of biomedical experiment. The need for a formal description of the experimental scheme is postulated. One of the ways of formal representation of the biomedical experiment based on the transition graph, which is one of the variants of the description of the finite state machine, is considered. The description revealed that the main characteristics of this representation are the correctness and adequacy of the representation in the form of a graph of transitions. The problem of description of nested sequences of actions corresponding to the beginning and end of the use of different components of the experiment is considered. An example of such use is the serial and parallel activation of experimental equipment. In this case, the correct sequences correspond to the implemented experiments, and the wrong ones correspond to the unrealizable ones. In this regard, there is a need to verify such feasibility. The necessity of checking the correctness of the graph as the main condition for the feasibility of the experiment is substantiated. One of the approaches to the analysis of the correctness of such a graph on the basis of matrix calculations is presented. The method of constructing the transition graph matrix is considered. The basic transformations necessary for checking the correctness of the transition graph of the biomedical experiment are given.

Injuries and diseases of the human locomotor appa ratus are an important medical and social problem, and the importance of this problem is now increasing.Pathology of spinal column is an important part of skeletal pathology, because the spinal column provides force balance in the human body. Pathology of the spinal column is observed in people of various age groups: dys plasia is the predominant pathology of spinal column in children; injuries and infections are predominant pathologies of the spinal column in young people of working age; degeneration, dystrophy, and tumors are predominant pathologies of the spinal column in elderly people. Modern orthopedic practice requires solution of complex diagnostic and therapeutic problems based on progress in science and technology. Automatic informa tion systems provide new opportunities for diagnosis and therapy. Such systems are used for treatment of various diseases of the spinal column. Diagnosis of spinal column fracture is fairly obvious because of clear X ray and clini cal semiotics. However, interpretation of spondylograms requires adequate information about spinal column dam age and normal spinal column X ray anatomy. Chronic degenerative, dystrophic, and tumoral spinal column pathologies are particularly difficult to diagnose.Diagnosis of spinal column pathology in modern orthopedic vertebrology includes X ray examination as well as orthopedic, neurosurgical, and radiological expert evaluation. The use of computer high technology is very promising for diagnosis and therapy of spinal column pathology. However, contemporary methods of X ray diagnosis of early and subclinical stages of spinal column pathology are insufficiently effective because they do not provide adequate estimates of mineral density of bone tis sue. In addition, the methods of X ray diagnosis exert radiation load on patients and medical personnel. Methods of magnetic resonance tomography, computer tomography, and densitometry are rather expensive, which imposes limitation on their use. The X ray pattern represents structure rather than function of bone tissue. Stabilometry provides indirect estimates of force balance of the human body. It should be noted that methods of spinal column pathology diagnosis based on mechanical properties of the spinal column are insufficiently used. Spinal column pathology primarily modifies elastic prop erties of spinal column segments. It should be also noted that mechanical load is characteristic of the human loco motor system. Examination of human body reaction to dosed mechanical load dates back to the XIX century. In 1890, V. M. Bekhterev suggested a device for examination of knee reflex [3]. This device was based on a mechanical pendulum with a standard weight and amplitude. This method was not widely used because of lack of sensitive sensors and automatic systems of data processing.There are methods of postmortem determination of spinal column strength, but they cause spinal column destruction [4]. There are methods based on sound prop agation in bone tissu...

The aim of the work is to develop a conceptual approach to decision support in assessing the functional state of a complex system of biological type. The definition of the functional state and the basic principles of its evaluation for complex systems of biological type on the basis of system representations are formulated. A situational model of the problem environment as a set-theoretic composition of the main components and evaluation functions was developed, which allowed to formulate the definition of the problem situation. The structure of the application of data mining to assess the functional state of a complex system using as feedback models of three levels-strategic, tactical and operational. A system of coordinated models for decisionmaking in assessing the functional state of a complex system based on causal representations in the form of Markov chains and Petri nets is proposed.