The active moiety with poor solubility is posing a challenge in drug development which may reduce the effectiveness in patients when administered orally. Cocrystal formation is one of the latest approaches for improving the various parameters of a drug molecule such as solubility, melting point, pharmacokinetic, pharmacodynamic, and bioavailability. Cocrystals are crystalline single state materials composed of two or more than two different molecular amalgams held together in a fixed stoichiometric ratio. There are various techniques used for the preparation of cocrystals such as solvent evaporation, grinding, and cooling crystallization. The quantitative and qualitative aspects of these cocrystals are evaluated using various validated instruments such as nuclear magnetic resonance, powder X-ray diffraction, and differential scanning calorimetry.

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Alpha amylases cleave the starch like molecules and led to increase in blood sugar level in diabetic patients then in order to manage it the inhibition action is carried out by their inhibitors. The α-amylase inhibitors catalyses the process of endo-hydrolysis of α (1→ 4) glycosidic linkage present in starch which ultimately led to decrease in the starch hydrolysis process. It also affects the carbohydrate absorption in the intestine. In 1945, the first alpha amylase inhibitor was reported from beans. It has already been isolated from various plant species namely, Hibiscus sabdariffa.L, Geranium pratense L and Cedrus libani A. Rich with inhibition percentage of 100, 43 and 31 respectively. The studies have already been reported on inhibitors and their interactions with human pancreatic alpha amylases are made .In-vitro and in vivo tests has already been done by various researchers which showed a significant drop in blood sugar level of a normoglycemic mice after an extract from the leaves of Bersama abbyssinica was tested for its potential effect as anti-diabetic.

For masses of years, flora and herbs had been an amazing supply of meals and medication. Surveys performed in indigenous locations discovered that the Sida acuta had many regional conventional usages. This broom weed is a perennial plant that produces slightly woody stems and is harvested from the wild as a source of local medicine and fiber. In tropical countries, indigenous people used this plant to treat common illnesses which include fever, headache, and various infections. Scientifically, Sida acuta has already been studied for several potential benefits. Studies reveal that roots of Sida acuta can be chewed to relieve toothache and leaves are soaked in water to make hair conditioner or shampoo to treat scaly skin. Apart from these benefits, it is also being known for repressing the potential of parthenium (poisonous herb) species through an allopathic control over it. . This review article mainly focuses on therapeutic applications of Sida acuta and in addition, its components, advanced usages, bioactive compounds, and essential micronutrients are also discussed.