Nicotinic acetylcholine
receptors (nAChRs) comprise a large and
ancient family of allosteric ion channels mediating synaptic transmission.
The vast knowledge about nAChRs has become difficult to navigate.
NAChRDB is a web-accessible resource of curated residue-level functional
annotations of neuromuscular nAChRs. Interactive three-dimensional
(3D) visualization and sequence alignment give further context to
this rich and growing collection of experimental observations and
computational predictions. NAChRDB is freely available at
, with interactive tutorials and regular updates to the content and
web interface. No installation or user registration is required. NAChRDB
is accessible through any modern internet browser on desktops and
mobile devices. By providing immediate and systematic access to practical
knowledge gained through decades of research, NAChRDB represents a
powerful educational tool and helps guide discovery by revealing gaps
in current knowledge and aiding the interpretation of results of molecular
and structural biology experiments or computational studies.
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