An interesting synthetic transformation of protection–deprotection chemistry in an isatin molecule is achieved. Morita–Baylis–Hillman (MBH) adduct formation used as protection of the C-3 position in the isatin molecule is reported. C–C bond cleavage in the MBH adduct of isatin with the help of phenylhydrazine and C=N bond cleavage in the phenylhydrazone derivative of isatin with the help of K10 clay are studied systematically and reported as deprotection.

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