No abstract

liposomal encapsulation of cytarabine and daunorubicin that delivers a synergistic drug ratio. Compared with 7+3, CPX-351 improves overall survival in older adults with untreated high-risk or secondary AML and differs in its mode of administration. The purpose of this study was to estimate health state utilities associated with AML treatment strategies. Methods: In time trade-off interviews with a 1-year time horizon, participants from the UK general population (London, Edinburgh) valued 12 health states drafted based on literature and clinician interviews. To identify disutility associated with chemotherapy, two types of induction and four types of consolidation were added to an otherwise identical health state describing AML in temporary remission. The decrease in utility when adding these treatment regimens represents the disutility of each type of induction/consolidation. Five additional health states were valued to estimate utilities associated with other AML treatments. Results: 200 participants completed interviews. Mean (SD) utilities were 0.55 (0.31) for pre-treatment AML and 0.66 (0.29) for AML in temporary remission. The addition of any chemotherapy to one year of temporary remission significantly decreased utility (P < 0.0001). Induction had a mean disutility of-0.11 with CPX-351 and-0.15 with 7+3. Mean disutility for consolidation ranged from-0.03 with outpatient CPX-351 to-0.11 with inpatient 5+2. Utilities were also assessed for other AML treatments (e.g., BMT, low-intensity regimens). ConClusions: Induction and consolidation chemotherapy were consistently associated with decreases in health state utility values, but consistently less disutility was seen with CPX-351 versus 7+3 across treatment phases. These utilities may be useful in cost-utility models comparing the value of AML treatments.

Objectives: Cancer is one of the leading causes of death in Europe, accounting for 21% of all deaths. In recent years, several studies have been conducted to gather information on preferences in cancer treatment. Especially discrete choice experiments (DCE) are of growing importance in the field of preference measurement. This study aimed at aggregating which aspects of cancer treatment were included in DCEs and which were most important for patients, physicians, other healthcare professionals, and the general population. Methods: A systematic literature search (up to April 2019) was conducted using MEDLINE and EMBASE to identify DCEs investigating preferences in cancer treatment. Inclusion criteria were: DCE as elicitation method, focus on cancer treatment, study conducted in Europe, and journal articles published in English. Identified studies were analyzed in terms of year of publication, study country, study participants, specific indication and relative importance of attributes, which were classified into specific attributes such as outcome and procedure. Results: A total of n=25 studies were identified that elicited preferences for cancer treatment using a DCE. Seven studies were multi-country studies including two or more countries and most of them were conducted in the UK (n=13), Germany (n=11), and France (n=6). In about two thirds of the identified DCEs, patients were the study subject. Preferences were assessed most frequently for prostate cancer (n=4), basal cell carcinoma (n=4), and lung cancer (n=4). Outcome attributes, such as progression free survival or the occurrence of adverse events showed the highest relative importance in most of the studies, regardless of the study subjects. Conclusions: Although the type of procedure, the organization, costs, and patient or disease-specific attributes had a significant impact on the preferences in cancer treatment for participants, outcome attributes were of highest importance when choosing different cancer treatment options.

Objectives: The potential high-unintended pregnancy rates have resulted in great productivity loss in China. Several contraceptive methods have been introduced by both the providers and the woman themselves to reduce the unintended pregnancy rates.A cost-benefit analysis on various hormonal contraceptive methods was performed in order to provide references for contraception selection in China. MethOds: A decision-tree model was used to compare contraception costs and effects among different contraceptive methods. All women were classified into three contraception profiles (continuation, discontinuation and switch, discontinuation and drop-out).Outcomes included no pregnancy, pregnancy with no birth and birth. All the probabilities, medical and medication data in this model were derived from the literature and interviews. Results: A comparison of total estimated yearly and cumulative costs indicated that contraceptive implants, transdermal contraceptive, extended-cycle OC, vaginal ring, and IUD were less costly, less than $281733.7 in a three-year study period. While transdermal contraceptive, extended-cycle OC and vaginal ring were not available in the Chinese market, contraceptive implants and IUD were the only two choices in China with lowest cumulative costs. The further cost-benefit analysis also demonstrated contraceptive implants as good value for money. Using contraceptive implants were proved to have the lowest cost of pregnancy from failure of $839.9, with a total cost of $26814.9, and a benefit-cost ratio of 2.2, far over 1.0. Sensitivity analysis by tornado diagrams showed that cost of pregnancies, age and proportion of discontinuation and switch might have the greatest impact on the costs and failure risks of contraceptive implants. cOnclusiOns: In order to reduce the unintended pregnancy rates, the implementation of hormonal contraception may lead to a benefit in terms of both costs and effects. And among all the hormonal contraception in the Chinese market, contraceptive implants tend to generate greater economic benefits. Note:1US dollar= 6.46 Chinese yuan.Objectives: China is a big country with a large population. Reproductive health education is not sufficient for women of childbearing age, which leads to high unintended pregnancy (UP) rate. These represent a significant cost to the health care system. This study analyzes the epidemiology and productivity loss of unintended pregnancy in China. MethOds: The study reviewed published scientific articles and policy documents related to unintended pregnancy in China. We retrieved literature from Wanfang and PubMed databases, and searched policy documents in websites of National Bureau of Statistics and National Center for Women and Children's health, China CDC. Results: Almost 10% of fertile women have UP in China each year. There are four different results of UP, including miscarriage, elective abortion, ectopic pregnancy and delivery. There are two methods of elective abortion, including operation abortion and drug abortion. The costs of operation a...

A851sam ser convertidos de forma positiva quando aplicados à pesquisa e ao treinamento de recursos humanos. Assim, as isenções podem alcançar todos os tipos de tributo (impostos, taxas, contribuições de melhoria, empréstimos compulsórios e contribuições especiais). Cada esfera de Governo (federal, estadual e municipal) legisla sobre a isenção dos tributos de sua competência. A apresentação e a análise se darão conforme Portaria nº 1.826 / 2012 que veio como uma das regulamentações da Lei 12.101/2009. Para isso o Ministério da Saúde define e divulga anualmente os temas e objetivos prioritários para a elaboração de projetos de apoio ao desenvolvimento institucional do SUS, a serem executados em um período de três anos. ResultAdos: No âmbito da avaliação e gestão em saúde, a entidade de saúde, reconhecida excelência, está apta a apresentar projetos PROADI-SUS no âmbito da Avaliação e Incorporação de Tecnologia no SUS. No triênio 2012 -2014 foram contempladas 5 instituições no programa. Vários projetos foram aprovados envolvendo um valor estimado de R$ 90.097.871,53 reais. ConClusões: O programa Proadi-SUS favorece ao SUS a construção de conhecimentos e práticas sustentáveis ao sistema de saúde, por meio de uma parceria público-privada, entre o Estado e a sociedade. Nesse triênio (2012 -2014), cerca de 3660 pessoas foram especializadas ou qualificadas em 2013 e serão concluídos até 2014, 37 estudos e 2 pesquisas. Os resultados desses projetos orientaram tomada de decisões de gestores, assim como a melhoria dos serviços prestados a sociedade com profissionais especializados e qualificados. PHP26 CaraCterizaCión de PaCientes Con MúltiPles enferMedades CróniCas desde la PersPeCtiva del aseguraMiento en ColoMbia