Zirconium-based metal-organic frameworks (Zr-MOFs) have been synthesized onto diverse substrates however thermal and acidic conditions of synthesis processing impair or carbonize the polysaccharide based substrate. Also, MOF-coated polysaccharides usually show poor mechanical properties and instability in aqueous conditions unsuitable for biomedical applications. There is no report on the synthesis of MOFs on cellulosic substrate to preserve intactness. Here, an optimized Zr-MOFs synthesis method on cotton fabric is introduced to prepare a biomedically applicable Zr-MOFs modified cellulosic fabric. The resultant fabric demonstrates an absolute wash durability with enhanced hydrophilicity and better mechanical properties with higher Zr-MOFs content. The treated fabric shows 787% and 2105% improvement in absorption capacity for Salvia officinalis (SO) and Calendula officinalis (CO) extracts and the release kinetic model of diffusion mechanism. Cotton-MOF-SO and Cotton-MOF-CO confirm antibacterial activity of 99.2% and 37.4% against Escherichia coli and 19.9% and 35.3% against Staphylococcus aureus. Finally, the cotton-MOF-CO can be considered as a biocompatible material however cotton-MOF-SO exhibits high toxicity signifying its potentiality for inducing death to cancer cells.

Improvement of curative herbal extracts effectiveness through novel drug delivery systems is a field of study for the researches nowadays. Zirconium-based metal-organic frameworks (Zr-MOFs) are one of the most capable porous nanocarriers that need a biocompatible template to be used in biomedical applications. In this work, Zr-MOF was synthesized into the wool fabric through in-situ one-pot method with different molar ratios. The final fabrics were characterized thoroughly using various techniques and the effect of components on monodispersity and nucleation tendency of Zr-MOF onto the surface of wool were explained. The resultant fabric stablished absolute wash durability, increased air-permeability up to twice and reasonable hydrophilicity. Tensile strength and young modulus decreased 30 and 1244 % and strain increased 66 %. Salvia Officinalis (SO) and Calendula Officinalis (CO) extracts were loaded onto the modified fabrics with 1154 and 1842 % increased absorption capacity. The release profiles showed domination of diffusion mechanism. The wool-MOF-SO and CO displayed both 100 % antibacterial activity against Escherichia coli and 60.95 and 64.64 % against Staphylococcus aureus because of diverse antibacterial components. Calendula Officinalis proved biocompatibility with human skin however Salvia Officinalis exhibited high toxicity.

acid removal from water using a novel fabricated antifouling carbon nanotube bucky -paper membrane and effect of operating parameters, Global NEST Journal, 19(2), 217-224.Humic acid removal from water using a novel fabricated antifouling carbon nanotube bucky -paper membrane and effect of operating parameters AbstractIn present work, a novel supported bucky paper (BP) membrane was fabricated and evaluated for humic acid (HA) removal from water. For better understanding the effect of operating variables, response surface methodology (RSM) was also applied. Three independent parameters namely TOC concentration (5, 10 and 15 mg l -1 ), operating time (10, 20 and 30 min) and transmembrane pressure (TMP) (1, 2 and 3 bar) were selected for TOC removal (%) and permeate flux analysis.The results revealed that the membrane could effectively remove HA primarily through electrostatic repulsion and then adsorption mechanisms. The study also showed that about 65% and 35% of the removed HA were through repulsion and adsorption mechanisms respectively. Based on analysis of variance (ANOVA), it was showed that the effect of TMP was strongly significant on the removal and flux (P-value <0.05). In addition, statistical test confirmed that RSM based on the Box-Behnken was a suitable method for optimizing the main operating variables for HA rejection using BP membrane (R In general, the synthesized BP membrane showed a relatively good rejection of HA and revealed antifouling properties over the filtration time.