Mountainous river basins are one of the main sources of sediment. Over long time scales, sediment production is sustained by the persistent dissection of river basins, which is promoted by tectonic activity. The response or adjustment of rivers to forcing factors such as uplift is based on the concept of the graded river and a feedback mechanism between the incision and uplift. Although the development of graded rivers under natural circumstances has been discussed for a long time, knowledge about the transition of river basins under heterogeneous uplift is not enough. To understand the development of a river basin with a non‐uniform uplift rate, two simple cases are examined: landward and seaward tilting uplift, where the uplift rate varies linearly in space. For our study, laboratory experiments were conducted and the results were compared with those of natural river basins; two river basins in Yakushima Island were selected for this purpose. In both the laboratory and Yakushima, the longitudinal profile of the river basin under landward‐tilting uplift has a convex‐up zone and a specific knickpoint is formed at the upstream end of this zone. This knickpoint is inactive with respect to migration and incision owing to the insufficient cumulative uplift to the equilibrium state. It was also observed in both the experimental and natural cases that the profile of the river basin under seaward tilting is unlikely to have such a convex‐up zone in the long term, and will instead have a smooth concave profile. Therefore, the spatiotemporal pattern of dissection differs depending on the type of tilting uplift, which suggests that sediment production also varies in time and space according to the type of uplift.