Secondary phosphine
oxides incorporating various aryl and alkyl
groups were synthesized in racemic form, and these products formed
the library reported in this study. TADDOL derivatives were used to
obtain the optical resolution of these
P
-stereogenic
secondary phosphine oxides. The developed resolution method showed
a good scope under the optimized reaction conditions, as 9 out of
14 derivatives could be prepared with an enantiomeric excess (ee)
≥ 79% and 5 of these derivatives were practically enantiopure
>P(O)H compounds (ee ≥ 98%). The scalability of this resolution
method was also demonstrated. Noncovalent interactions responsible
for the formation of diasteromeric complexes were elucidated by single-crystal
XRD measurements. (
S
)-(2-Methylphenyl)phenylphosphine
oxide was transformed to a variety of
P
-stereogenic
tertiary phosphine oxides and a thiophosphinate in stereospecific
Michaelis–Becker, Hirao, or Pudovik reactions.
Several dialkyl‐arylphosphine oxides were prepared, and the enantioseparation of the corresponding racemates was elaborated with host–guest complexation using TADDOL‐derivatives. The crystallization conditions were optimized and two separate crystallization methods, one in organic solvent, and the other in water, were found to yield five examples of phosphine oxides with enantiomeric excess values higher than 94 %. A gram scale resolution was performed, and both enantiomers of the methyl‐phenyl‐propyl‐phosphine oxide were separated with (R,R)‐ or (S,S)‐spiro‐TADDOL. The intermolecular interactions responsible for the enantiomeric recognition between the chiral host and guest molecules were investigated by single‐crystal X‐ray diffractional structural determinations. The similarities in the structural patterns of a few diastereomeric crystals were checked by powder X‐ray diffraction, as well. Organic solvent nanofiltration (OSN) was used as a scalable technique for the decomposition of the corresponding phosphine oxide–spiro‐TADDOL molecular complexes, and for the recovery of the phosphine oxide enantiomers and resolving agents.
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