Background Graves’ disease (GD) is an autoimmune thyroid condition that causes hyperthyroidism in children and adolescents through stimulation by thyroid receptor antibodies. Objective The aim of this study is to determine the characteristics of Graves’ disease in children and adolescents in Medina, the Kingdom of Saudi Arabia, with comparison to those seen in other countries. Methods This is a retrospective chart review of children and adolescents diagnosed with Graves’ disease between January 2010 and May 2021. Results Fifty-eight patients aged 12. 02 ± 4.85 years were identified, of which 44 (75.9%) were females. Exophthalmos (63.8%), neck swelling (60.3%), palpitation (46.6%), and tremors (29.3%) were the most common presenting manifestations. Vitiligo and alopecia were the only autoimmune diseases seen in our patients with (1.72%) each. One (1.72%) patient was treated with radioactive iodine, 54 (93.1%) received carbimazole, and 6 (10.3%) underwent thyroidectomy. Conclusion In our study we found that Graves’ disease is more common in females. Neck swelling, palpitation, and tremor were the main manifestations. Compared with other countries, there was a higher frequency of exophthalmos and lower frequencies of associated autoimmune conditions. The primary treatment was antithyroid medication, whereas thyroidectomy and radioiodine were used less frequently. Presentation: No date and time listed