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There are two molecules in the asymmetric unit of the title compound, C12H23N3S, which are linked by two strong N—H...S hydrogen bonds, building a non-centrosymmetric dimer with graph-set motifR22(8). The molecules are further connected by N—H...S interactions into a two-dimensional hydrogen-bonded polymeric structure along the [001] direction. The absolute structure is based on the refinement of the Flack parameter.

The mol­ecule of 5-nitro­isatin-3-phenyl­hydrazone deviates slightly from a planar geometry. In the crystal, mol­ecules are linked by hydrogen bonding into a two-dimensional polymer along (120), forming rings of graph-set motifs (8), (26), (32) and S(6). In addition, mol­ecules are stacked along the [100] through C=O⋯Cg inter­actions, as suggested by the Hirshfeld surface, which also indicates that the most important contributions for the crystal structure cohesion are O⋯H (28.5%) and H⋯H (26.7%) inter­actions. An in silico evaluation of the title compound with the di­hydro­folate reductase enzyme was performed and N—H⋯O and Cg⋯Cg inter­actions were found.

There are two mol­ecules in the asymmetric unit of the title compound, one of them being disordered over the methyl group. The mol­ecules are linked by weak H⋯S inter­actions into chains with graph-set motifs C(4) along [100] and and (10) rings. The Hirshfeld surface calculation suggests that the most important contribution for the crystal structure are the H⋯H inter­actions (64.20%).

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