Background and Objectives:The purpose of this study was to evaluate total antioxidant levels in caries-free and caries-active children.Materials and Methods:The present study included one hundred and twenty healthy children who were divided into two groups; Group I and Group II, comprising of age groups 7 to 10 years and 11 to 14 years. respectively. Both the groups were then sub-divided equally according to gender. They were further divided into caries-free and caries-active children with 15 children in each group. Unstimulated saliva was collected by suction method. The samples were then analyzed for total antioxidant capacity. The data was then statistically analyzed using Student's t-test (unpaired).Results:The results revealed that the total antioxidant capacity of saliva increased significantly in caries-active children when compared to caries-free children.Conclusion:Within the limitation of this study, we can conclude that the physicochemical properties of saliva in particular total antioxidant capacity play a role in the development of caries.

Background: Periodontal disease constitutes a group of diseases involving inflammatory aspects of the host caused by several microbial agents that affect periodontal tissues and could have systemic implications. Objective: The present study was conducted to assess the correlation of COVID-19 infection and severity of periodontitis in subjects who has mild form of the disease as compared to subjects having moderate form of the disease. Materials and Methods: The study included 116 subjects suffering from COVID-19 that were equally divided into two groups, each based on a convenient sampling methodology. Group I had a moderate form of COVID that required hospitalization and Group II had a mild form of COVID and were treated at home. The stage of periodontal disease was assessed in both groups. Also, laboratory parameters such as level of C-reactive protein (CRP), white blood cell (WBC), D-dimer, vitamin D, and lymphocytes were also assessed. Statistical analysis was done using Chi-square and multiple logistic regression analysis. Results: More than 75% of subjects in both groups were non-smokers. Subjects having more than one comorbid condition were more in number in Group I (51.7%) as compared to Group II (24%). Severe periodontitis (stages 2–4) was found in 81% of subjects in Group I and 46.2% of subjects in Group II [ Figure 1 ]. The odds of getting severe periodontal disease were 6.32 times more in subjects belonging to Group I as compared to Group II. Subjects having more than one comorbid condition were 4.43 times at risk of severe periodontitis as compared to subjects with no co-morbidity Conclusion: Severe form of periodontal disease was associated with moderate-to-severe COVID-19 infection and levels of lymphocytes, WBCs, and CRP were elevated in subjects belonging to Group I.

Local anesthetic agents are widely used in dentistry. It has major role in all field of dentistry especially in oral surgery, Pediatrics, Endodontics, Periodontics etc. The only drawback associated with LA is that occurrence of soft tissue anaesthesia can persist for three to five hours, while the procedure itself usually lasts for less than an hour. Patients experience limitation of function in terms of speech difficulty, drinking neating etc. All these events leave negative impact on minds of patients; hence they avoid visiting dental offices. In order to reverse these events, a new drug named OraVerse (phentolamine mesylate) is available to us. This drug is known for its LA reversal ability and effects of local dental anaesthetic.

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