<p>There are a lot of various kinds of plants such as Black Cumin <em>(Nigella sativa L.)</em> which is believed by the people to increase HDL and decrease LDL levels in the blood.</p><p>The purpose of this experiment<strong> </strong>to know the effect of extract black cumin seeds <em>(Nigella sativa L.)</em>can increase HDL and decrease LDL cholesterol levels of white rats <em>(Rattus norvegicus)</em>.</p><p>This experiment using 24 of rats which divided into 4 groups, namely the negative control group, positive control group, the treatment group one dosage 126 mg/KgBWand the treatment group two dosage 252 mg/KgBW. This research was carried out for 28 days and continued by termination.</p><p>In the One way ANOVA test, HDL levels obtained significant values of 0.134 and LDL levels of 0.070 which means p&gt; 0.05 and showed that black cumin seed extract (Nigella sativa L.) there’s no different.</p><p>The conclusion of the experiment is giving black cumin seed extract <em>(Nigella sativa L.) </em>had no effect for increasing HDL and decreasing LDL cholesterol levels of white rats <em>(Rattus norvegicus)</em>.</p><p><strong>Keywords: </strong> black cumin seed extract, HDL cholesterol levels, LDL cholesterol level, <em>(Nigella sativa L.)</em>.</p><p><strong> </strong></p>