<p>There are a lot of various kinds of plants such as Black Cumin <em>(Nigella sativa L.)</em> which is believed by the people to increase HDL and decrease LDL levels in the blood.</p><p>The purpose of this experiment<strong> </strong>to know the effect of extract black cumin seeds <em>(Nigella sativa L.)</em>can increase HDL and decrease LDL cholesterol levels of white rats <em>(Rattus norvegicus)</em>.</p><p>This experiment using 24 of rats which divided into 4 groups, namely the negative control group, positive control group, the treatment group one dosage 126 mg/KgBWand the treatment group two dosage 252 mg/KgBW. This research was carried out for 28 days and continued by termination.</p><p>In the One way ANOVA test, HDL levels obtained significant values of 0.134 and LDL levels of 0.070 which means p&gt; 0.05 and showed that black cumin seed extract (Nigella sativa L.) there’s no different.</p><p>The conclusion of the experiment is giving black cumin seed extract <em>(Nigella sativa L.) </em>had no effect for increasing HDL and decreasing LDL cholesterol levels of white rats <em>(Rattus norvegicus)</em>.</p><p><strong>Keywords: </strong> black cumin seed extract, HDL cholesterol levels, LDL cholesterol level, <em>(Nigella sativa L.)</em>.</p><p><strong> </strong></p>

<p class="ABSTRACT">Background. Non-alcoholic fatty liver disease (NAFLD) causes many health problems in overweight person. There is an increase in the incidence of NAFLD with the increased incidence of metabolic syndrome. NAFLD is closely related to the incidence of obesity and dyslipidemia. Increased levels of AST and ALT are the most frequently performed liver function tests that can be used as a benchmark for suspicion of NAFLD. Banana peels contain flavonoids and phenolics which are antioxidants that can function as hepatoprotectors.</p><p class="ABSTRACT">Aim. Proving the effect of Kepok banana peel extract (Musa paradisiaca formatypica) on AST and ALT of Wistar rats induced high fat diet.</p><p class="ABSTRACT">Method. A laboratory experimental study with a post-test only control group design, with four treatment groups. There is one negative control group only given four weeks standard diet, one positive control group only given four weeks high-fat diet, and two treatment group where the rats were given two weeks high-fat diet then were given two weeks high-fat diet plus Kepok banana peel extract at a dose of 200 mg/kg BW and 400 mg/kg BW.</p><p class="ABSTRACT">Result. Based on the results of descriptive analysis, the highest mean AST levels were in the negative control group and the lowest was the K2 group. Meanwhile, the highest mean of ALT was in the positive control group and the lowest was the K2 group. Based on the Kruskal Wallis test, the significance of the AST variable was not different (p&gt;0.05), but the ALT variable was significantly different (p&lt;0.05). Significant differences from the Mann Whitney-U test (p&lt;0.05) were obtained between the negative control group and the positive control, the negative control group with K2 and the positive control group with the K2 group).</p><p class="ABSTRACT">Conclusion. The administration of Kepok banana peel extract (Musa paradisiaca formatypica) showed a significant decrease in ALT levels in Wistar strain white rats induced by a high-fat diet, but it was not significant for AST levels.</p>

The prevalence of obesity in women in Indonesia is increasing. Obesity is characterized by excess BMI and fat mass in the body. High body fat mass is associated with metabolic diseases and blood pressure (BP). The research design was cross-sectional, involved the students of the Faculty of Medicine, Universitas Hang Tuah Surabaya in July 2019. Sampling was done using stratified random sampling with 48 female volunteers who were grouped into 16 volunteers each semester. In students of Semester II, the average BMI was 21.2±2.4 kg/m2, Skinfold Thickness (SFT) 54.6±9.9 mm, BP 109±9.6/71±8.3 mmHg. In students of Semester IV, the average BMI was 23±3.5 kg/m2, SFT 48±14.10 mm, BP 109±9.7/77±7 mmHg. In students of Semester VI, the average BMI was 24.33±4.72 kg/m2, SFT 69.87±21.54 mm, BP 122±8.9/84±11mmHg. The correlation coefficient of SFT and Systolic Blood Pressure (SBP) was 0.697, SFT and Diastolic Blood Pressure (DBP) was 0.362, BMI and SBP was 0.355, while BMI and DBP 0.171. There was a correlation between SFT and SBP and DBP, BMI and SBP in female students of semester II, IV and VI. Keywords: skinfold thickness (SFT); body mass index; blood pressure