Masyarakat modern saat ini mengalami perubahan gaya hidup yang mengakibatkan perubahan pada pola konsumsi makanan menjadi pola makanan yang tinggi lemak jenuh, tinggi gula dan rendah serat. Hal tersebut sering berakibat tingginya asupan makanan yang berkolesterol tunggi kemudian ditambah dengan seringnya frekuensi makan serta konsumsi sayur dan buah yang rendah, akan berpotensi menyebabkan kegemukan. stroke, aterosklerosis dan penyakit jantung koroner (PJK) memiliki faktor risiko paling besar menjadi  penyakit serius di masyarakat yaitu hiperlipidemia sehingga diduga menjadi penyebab kesakitan dan kematian di negara adidaya dan berkembang. Membuktikan pengaruh ekstrak biji mahoni terhadap kadar MDA plasma tikus putih jantan galur wistar yang diberikan diet tinggi lemak. 32 ekor tikus dikelompokkan dalam kelompok kontrol negatif yang diberikan diet standart, kontrol positif yang diberikan diet tinggi lemak dan perlakuan yang mendapatkan diet tinggi lemak bersama ekstrak biji mahoni dengan dosis 100 mg/ kgBB dan 200 mg/kgBB. Diet tinggi lemak dikonsumsi tikus selama 14 hari dan pada hari ke 15 pada kelompok perlakuan ditambahkan ekstrak biji mahoni dengan dosis 100 mg/ kgBB dan 200 mg/kgBB  Derajat stres oksidatif diukur dengan menggunakan indikator malondialdehyde (MDA). Kelompok kontrol negatif menunjukkan kadar MDA 78,5±16,92 µg/ml. Kelompok kontrol positif menunjukkan kadar MDA 97,17±26,559 µg/ml. Kelompok perlakuan yang mendapatkan diet tinggi lemak dan ekstrak biji mahoni dengan dosis 100 mg/kgBB, kadar MDAnya 65,25±24,126 µg/ml dan yang mendapatkan diet tinggi lemak dan ekstrak biji mahoni dosis 200 mg/kgBB 82±22,836 µg/ml. Uji ANOVA tidak mendapatkan hasil dengan perbedaan yang bermakna (p=0,151).

Diabetes mellitus is a chronic hyperglycemic syndrome that can be accompanied by lipid metabolism disorders. Alloxan is a diabetogenic agent that is associated with an increase in LDL cholesterol levels. Patin fish contain omega-3 and oleic acid, which can potentially reduce or control LDL cholesterol levels. This study aims to determine the effect of Patin fish (Pangasius hypothalmus) oil extract on LDL cholesterol levels of alloxan-induced Rattus norvegicus. The method of this study is the post-test-only control group design. Twenty-seven experimental animals were divided into 3 groups; (1) the 1st group was without treatment, (2) 2nd group was induced with 150 mg/kg BW alloxan on the 7th day; (3) 3rd group was induced with 150 mg/kg BW alloxan on the 7th day and given the Patin fish oil extract at a dose of 73 mg/kg BW on the 10th day for 14 days. Blood samples were taken on the 24th day to determine LDL cholesterol levels. The results of the One-Way ANOVA test showed a significant mean difference, p=0,001 (p<a). The results of the Post-Hoc LSD test showed a meant difference between the 1st group and the 2nd control group p=0,001 (p<a); 2nd group and 3rd group p=0,026 (p<a); between the 1st group and the 3rd group p=0,015 (p<a). Giving alloxan 150 mg/kg BW can significantly increase LDL cholesterol levels of Rattus norvegicus and administration of Patin fish oil extract 73 mg/kg BW can significantly reduce LDL cholesterol levels of Rattus norvegicus.

<p class="ABSTRACT">Background. Non-alcoholic fatty liver disease (NAFLD) causes many health problems in overweight person. There is an increase in the incidence of NAFLD with the increased incidence of metabolic syndrome. NAFLD is closely related to the incidence of obesity and dyslipidemia. Increased levels of AST and ALT are the most frequently performed liver function tests that can be used as a benchmark for suspicion of NAFLD. Banana peels contain flavonoids and phenolics which are antioxidants that can function as hepatoprotectors.</p><p class="ABSTRACT">Aim. Proving the effect of Kepok banana peel extract (Musa paradisiaca formatypica) on AST and ALT of Wistar rats induced high fat diet.</p><p class="ABSTRACT">Method. A laboratory experimental study with a post-test only control group design, with four treatment groups. There is one negative control group only given four weeks standard diet, one positive control group only given four weeks high-fat diet, and two treatment group where the rats were given two weeks high-fat diet then were given two weeks high-fat diet plus Kepok banana peel extract at a dose of 200 mg/kg BW and 400 mg/kg BW.</p><p class="ABSTRACT">Result. Based on the results of descriptive analysis, the highest mean AST levels were in the negative control group and the lowest was the K2 group. Meanwhile, the highest mean of ALT was in the positive control group and the lowest was the K2 group. Based on the Kruskal Wallis test, the significance of the AST variable was not different (p&gt;0.05), but the ALT variable was significantly different (p&lt;0.05). Significant differences from the Mann Whitney-U test (p&lt;0.05) were obtained between the negative control group and the positive control, the negative control group with K2 and the positive control group with the K2 group).</p><p class="ABSTRACT">Conclusion. The administration of Kepok banana peel extract (Musa paradisiaca formatypica) showed a significant decrease in ALT levels in Wistar strain white rats induced by a high-fat diet, but it was not significant for AST levels.</p>

Background: Hypercholesterolemia is a risk factor for causing death at a young age. The World Health Organization reported in 2002 that 4.4 million deaths were caused by hypercholesterolemia, or 7.9% of the total number of deaths at a young age. Hypercholesterolemia is a condition in which cholesterol levels in the body exceed normal levels. One way that can be done to prevent hypercholesterolemia is to control diet, namely by fasting. Dawood’s fasting is one of the obligatory fasts of Islamwhich is done with one-day fasting and one-day not. Objective: This study aims to determine the effect of Dawood’s fasting in reducing total blood cholesterol levels in Hidayatullah Islamic Boarding School students in Surabaya.Methods: This study was designed with a quasi-experimental study research method using a comparative pre-test post-test non-equivalent control group design. The sample in this study was divided into two groups, namely one control group and one treatment group from the sample selected by purposive sampling. The population studied were students of the Hidayatullah Islamic Boarding School in Surabaya. Result: The results of statistical analysis using the Wilcoxon signed-rank test showed an effect of Dawood’s fasting in reducing total blood cholesterol levels in Hidayatullah Islamic Boarding School students in Surabaya.Conclusion: From research result that has been done, it can be concluded that there is an effect of Dawood’s fasting in reducing total blood cholesterol levels in Hidayatullah Islamic Boarding School students in Surabaya. Keywords: Dawood’s fasting, total blood cholesterol.

Background: Intermittent fasting is done with one day of fasting and one day of eating as usual so that it can reduce oxidative stress, inhibit apoptosis and tissue damage which will reduce degenerative diseases. Fasting can activate SIRT1 and SIRT3 to prevent apoptosis by decreasing reactive oxygen species and inhibiting the mitochondrial permeability transition pore component. The accumulation of free radicals is one of the mechanisms that play a role in liver damage so that the SGOT enzyme present in the liver cells will leave and enter the blood circulation, so that the number of these enzymes in the blood increases. Objective : To prove that there was a decrease in the levels of SGOT (Serum Glutamic Oxaloacetic Transaminase) in male white rats (Ratus norvegicus) of the wistar strain which were fasted intermittently by the Daud fasting method after being induced by Paracetamol. Method : The research design used is a laboratory experimental research type where the method used is randomized the post only control group design. The experimental animals used were white rats (Rattus norvegicus) wistar strain 2-3 months old with an initial body weight of 150-200gr as many as 32 tails. During the fasting treatment, the research subjects were not given diet and drinking, while the non-fasting subjects were given a standard diet and drank regularly were divided into four groups, namely negative control with a water probe that was filtered for 10 days and 1ml of 1% CMC-Na, positive control with a probe. filtered water for 10 days and induction of paracetamol 400mg/kgBW, treatment 1 with standard diet and induction of paracetamol and treatment 2 with intermittent fasting and induction of paracetamol. Results: The results of this study indicate that One-Way ANOVA test obtained p value = 0.384. (p > 0.05) then H0 was accepted, there was no significant difference between the SGOT levels of the experimental animal group that was given a standard diet, the experimental animal group that was given intermittent fasting, the experimental animal group that was given a standard diet and paracetamol and the experimental animal group that was given intermittent fasting and paracetamol treatment. Conclusion:  There is no effect of intermittent fasting with the Dawood fasting method on decreasing SGOT levels in male white rats (Rattus norvegicus) Wistar strain induced by paracetamol. Keywords: intermittent fasting, SGOT, paracetamol