Since 1963, evidence has accumulated that suggests boron is a safe and effective treatment for some forms of arthritis. The initial evidence was that boron supplementation alleviated arthritic pain and discomfort of the author. This was followed by findings from numerous other observations epidemiologic and controlled animal and human experiments. These findings included a) analytical evidence of lower boron concentrations in femur heads, bones, and synovial fluid from people with arthritis than from those without this disorder; b) observation evidence that bones of patients using boron supplements are much harder to cut than those of patients not using supplements; c) epidemiologic evidence that in areas of the world where boron intakes usually are 1.0 mg or less/day the estimated incidence of arthritis ranges from 20 to 70%, whereas in areas of the world where boron intakes are usually 3 to 10 mg, the estimated incidence of arthritis ranges from 0 to 10%; d) experimental evidence that rats with induced arthritis benefit from orally or intraperitoneally administered boron; e) experimental evidence from a double-blind placebo-boron supplementation trial with 20 subjects with osteoarthritis. A significant favorable response to a 6 mg boron/day supplement was obtained; 50% of subjects receiving the supplement improved compared to only 10% receiving the placebo. The preceding data indicate that boron is an essential nutrient for healthy bones and joints, and that further research into the use of boron for the treatment or prevention of arthritis is warranted.

Since 1963, evidence has accumulated that suggests boron is a safe and effective treatment for some forms of arthritis. The initial evidence was that boron supplementation alleviated arthritic pain and discomfort of the author. This was followed by findings from numerous other observations epidemiologic and controlled animal and human experiments. These findings included a ) analytical evidence of lower boron concentrations in femur heads, bones, and synovial fluid from people with arthritis than from those without this disorder; b) observation evidence that bones of patients using boron supplements are much harder to cut than those of patients not using supplements; c) epidemiologic evidence that in areas of the world where boron intakes usually are 1.0 mg or less/day the estimated incidence of arthritis ranges from 20 to 70%, whereas in areas of the world where boron intakes are usually 3 to 10 mg, the estimated incidence of arthritis ranges from 0 to 10%; d) experimental evidence that rats with induced arthritis benefit from orally or intraperitoneally administered boron; e) experimental evidence from a double-blind placebo-boron supplementation trial with 20 subjects with osteoarthritis. A significant favorable response to a 6 mg boron/day supplement was obtained; 50% of subjects receiving the supplement improved compared to only 10% receiving the placebo. The preceding data indicate that boron is an essential nutrient for healthy bones and joints, and that further research into the use of boron for the treatment or prevention of arthritis is warranted. -Environ Health Perspect 102(Suppl 7): 83-85 (1994)

3Cracoe House Cottage, Cracoe Near Skipton, North Yorkshire BD23 6LB, UK This report describes the conduct and results of a double-blind trial comparing oral intake of 6 mg of boron per day to placebo in the treatment of arthritis. The resultsindicate that boron may well be beneficial. Of the 10 patients on boron, five improved and five did not, but only one of the I0 patients on the placebo improved. This was essentially a pilot trial which showed that a small quantity of boron would greatly relieve severe osteo-arthritis. Of those starting the trial, 50% using boron improved as compared with 10% on placebo; or if we consider those who completed the trial, 71% improved while using boron. There were no side-eflects and these were sought. The indication is that boron (as sodium tetraborate decahydrate) are safe and beneficial in the treatment of osteo-arthritis and that firther research is required.

It has been suggested that boron deficiency in food may be a cause of some arthritis (Newnham 1979). Epidemiological studies were done to try to ascertain why some countries have more or less arthritis than other countries. Jamaica, Mauritius, Fiji and Israel were visited with a view to ascertaining the boron levels of locally consumed food as it was suspected that excessive use of soluble chemical fertilizers had damaged the soils of the sugar producing lands. Food grown on these soils were found to have low boron levels. By contrast the foods consumed in Israel had high boron concentrations associated with a low incidence of arthritis. South African work has shown that people who eat mostly maize have more arthritis when eating processed maize grown with fertilizer. Brief reference is made to the role of boron in human diets. There are bound to be geographical differences in dietary boron, but even in the USA levels have dropped considerably in 50 years. Arthritis is increasing, especially juvenile arthritis. The increased use of fertilizers and genetic selection of plants has led to a wide range of changes in the quality of foodstuffs and their nutrient content. The identification of the parallel loss of boron may reflect vital changes in trace elements and other nutrients.

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