Infeksi menular seksual (IMS) adalah infeksi yang penularannya terutama melalui hubungan seksual. World Health Organization (WHO) pada tahun 2016 menyatakan terdapat lebih dari 1 juta orang menderita IMS setiap hari. IMS memiliki pengaruh yang sangat besar pada kesehatan seksual dan reproduktif di seluruh dunia. Komplikasi dari IMS dapat menyebabkan kemandulan, gangguan kehamilan, gangguan pertumbuhan, kanker, dan memudahkan seseorang terkena infeksi human immunodeficiency diseases (HIV). Tingkat pengetahuan masyarakat diketahui berkorelasi dengan tingginya kejadian IMS di masyarakat khususnya remaja. Peningkatan pengetahuan dengan penyebaran informasi seperti kegiatan penyuluhan tentang IMS dan komplikasinya merupakan salah satu upaya penting yang harus dilakukan untuk mengurangi angka kejadian IMS di masyarakat. Kegiatan pengabdian kepada masyarakat (PPM) berupa penyuluhan ini dilakukan di SMA Negeri Jatinangor, Kecamatan Jatinangor, Kabupaten Sumedang. Peserta penyuluhan yaitu siswa dengan total peserta 50 orang. Pengumpulan data dilakukan dengan menggunakan kuesioner. Setiap lembar kuesioner terdiri dari 10 pertanyaan, yang meliputi definisi, jenis-jenis penyakit, cara penularan, tanda dan gejala, komplikasi, dan pencegahan IMS. Tingkat pengetahuan seluruh siswa SMA tentang IMS dan komplikasinya sebelum dilakukan penyuluhan masih cukup, yaitu 38,2% pertanyaan yang dapat dijawab dengan benar oleh peserta penyuluhan. Penyuluhan dapat meningkatkan pengetahuan siswa tentang jenis-jenis penyakit IMS dan komplikasinya. Siswa SMA diharapkan dapat menjadi ujung tombak dalam penyebaran informasi penyuluhan pada keluarga dan masyarakat, sehingga dapat menurunkan angka kejadian dan penularan IMS pada masyarakat.

Anogenital Warts (AGWs) are benign proliferations caused by Human Papillomavirus (HPV) infection on the genital or anal areas. Various therapeutic options are available for the treatment of AGWs but there is no best or ideal therapy, and the recurrence of AGWs is significantly high. A promising new therapy that is currently being evaluated is immunotherapy with the intralesional Bacillus Calmette-Guérin (BCG) vaccine. Two cases of a 23-year-old woman and a 41-year-old man were presented with manifestations of condyloma acuminata type AGWs. The patients were immunocompetent and received single dose intralesional BCG vaccine on the largest lesion. Clinical improvements of AGWs lesions were noted starting on the 14th day after receiving therapy by the disappearance of some lesions with no recurrence and side effects. Intralesional BCG vaccine activates the immune system, treats other AGWs lesions that do not receive an intralesional injection, and also prevents recurrence. Although the intralesional BCG vaccine is effective for treating AGWs, further evaluation is still needed for its recurrence.

Background: Cutaneous metastasis (CM) is a rare condition characterized by skin infiltration and cell proliferation from malignant tumor. Breast cancer is the most common primary malignancy causing CM. This retrospective study aimed to recognize the characteristics of CM from internal organ malignancies, based on the medical records from the Tumor and Dermatology Surgery Division, Department of Dermatology and Venereology, Dr. Hasan Sadikin General Hospital Bandung, Indonesia during October 2008-September 2018. Methods: The diagnosis of CM referred to clinical manifestations, histopathological, and immunohistochemical examinations. All medical records of patients contained gender and age, primary malignancy, clinical manifestations and location of skin disorders, time interval between diagnosis of primary malignancy and occurrence of CM, and mortality. Data were collected and evaluated descriptively. Results: A total of five subjects consisted of 3 patients with breast cancer, 1 patient with lung cancer, and 1 patient with prostate cancer. The subjects' age ranged from 40 to 49 years old (40%) and above 60 years old (40%) with the male to female ratio of 2:3. Breast cancer is found to be the most common malignancy (60%). All of the subjects had a skin lesion on the chest wall, abdomen, and back, and 60% of subjects had a nodule as a clinical manifestation. As much as 60% of subjects have died within four months after CM diagnosis was established. Conclusion: Breast cancer is the most common cause of CM. The CM's primary malignancies are affected by sex, age, clinical manifestations, predilection, and mortality characteristics.

Background A decision to diagnose certain skin diseases in patient undergoing psychotic break is challenging; this includes establishing the diagnosis of leprosy. Diagnosis of leprosy is established if there is at least one of the three cardinal signs of leprosy. Histopathological examination is not a gold standard, but remains useful in atypical or clinically suspicious cases. Case presentation We report for the first time, an interesting case of leprosy with atypical clinical manifestations in a psychotic homeless male with unknown history of present illness. Upon examination, hypopigmented macules, hyperpigmented macules, and plaques were observed, with unclear sensation impairment. Peripheral nerve thickening and acid-fast bacilli from slit-skin smear were not found. Histopathological examination from hypopigmented macule on the upper right limb showed no granulomatous reaction and other histopathological features of leprosy. Although the condition did not fulfill the cardinal signs of leprosy, we found lagophthalmos, claw hands, pseudomutilation of fingers and toes. Therefore, the diagnosis of suspected leprosy was established. The patient was hospitalized and attempts to administer oral rifampicin and clofazimine were made. Several days after treatment, annular erythematous macules appeared on the patient’s face, abdomen, and back. Histopathological examination results on sample taken from erythematous macule and right sural nerve were consistent with the diagnosis of leprosy with reversal reaction. Conclusion In certain conditions, histopathological examination of the skin and nerves are a highly rewarding test in establishing a diagnosis of leprosy.