Objectives Breast cancer (BC) in women could decrease health-related quality of life (HRQoL). HRQoL becomes important to be assessed to design a relevant treatment that could improve patient outcomes. Furthermore, assessing HRQoL by measuring health state utilities becomes pivotal for health economic evaluation. This study aimed to describe the HRQoL of postmenopausal women with hormone responsive (HR+) HER2− BC using the EQ5D5L instrument in Indonesia. Methods A cross-sectional study was conducted among 126 patients in Dr. Sardjito Hospital in Indonesia. The HRQoL was assessed by interviewing BC patients using the EQ5D5L questionnaire, and the utility index was calculated using the Indonesian value set. Information regarding clinical characteristic and socio-demographic were gained from patient medical records. One-way ANOVA and post-hoc Scheffe’s test was performed to compare the utility score within the health state. Results Of the 126 patients, a mean ± SD for the age of 59.2 ± 6.1 years. The major problems of patients were pain/discomfort (75.4%) followed by anxiety/depression (54.8%). The mean (SD) of EQ5D VAS was 76.64 (14.91). Mean (SD) of utility score was 0.87 (0.10), 0.77 (0.19) and 0.58 (0.44) for free metastasis (FM), locoregional metastasis (LM) and distant metastasis (DM), respectively. Poor QoL was observed at DM health state (p<0.05). Conclusions HRQoL of postmenopausal women with HR+ HER2− BC was low. The major reported problems were pain/discomfort and anxiety/depression.

Osteoartritis merupakan penyakit yang berkembang dengan lambat, biasa mempengaruhi terutama sendi diartrodial perifer dan rangka aksial. Secara umum prevalensi penyakit sendi di Indonesia sangat tinggi sebesar 30,3%. Sehingga diperlukan studi mengenai penggunaan obat anti-inflamasi non-steroid. Tujuan penelitian untuk Mengetahui hubungan rasionalitas penggunaan obat anti inflamasi non steroid dengan derajat Osteoarthritis pada usia lanjut. Penelitian ini menggunakan jenis penelitian observasi analitik dengan pendekatan waktu cross sectional. Instrument penelitian berupa rekam medic. Data dianalisis dengan uji Rank Spearman menggunakan Statistical Product and Servicer Solution (SPSS) versi 22. Dari 26 pasien yang diteliti 25 pasien yang sudah tepat cara pemberian obat dan derajat Osteoarthritis grade 1 sebanyak 9 pasien (36,0%), grade 2 sebanyak 9 pasien (36,0%), dan grade 3 sebanyak 7 pasien (28,0%). Mendapatkan nilai p value (0,210)>0,05 dengan nilai Rho – 0,255 bernilai negatif. Sedangkan hubungan antara tepat pemilihan obat dengan derajat Osteoarthritis data yang diperoleh dari penelitian sebanyak 26 pasien mendapatkan nilai p value (0,327)>0,05 dengan nilai Rho -0,200 bernilai negatif. Kesimpulan tidak terdapat hubungan yang signifikan antara rasionalitas penggunaan obat anti inflamasi non steroid dengan derajat Osteoarthritis di Rumah Sakit Islam Sunan Kudus.