Background and Objectives Postoperative complications (POCs) after hepatic resection for colorectal liver metastases (CRLM) adversely affect long‐term survival. The aim of this study was to analyze the effect of POC etiology and severity on overall survival (OS) and disease‐free survival (DFS). Methods A retrospective study of 254 consecutive hepatectomies for CRLM was performed. Univariate and multivariate analyses were performed to determine the effects of demographic, tumor‐related and perioperative variables on OS and DFS. A 1:1 propensity score matching (PSM) was then used to compare patients with different POC etiology: infective (Inf‐POC), noninfective (Non‐inf POC), and no‐complications (No‐POC). Results Inf‐POC, Non‐inf POC, and No‐POC patients represented 18.8%, 19.2%, and 62% of the sample, respectively. In univariate and multivariate analyses infectious POC were independent risk factors for decreased OS and DFS. After PSM, Inf‐POC group presented decreased OS and DFS when compared with Non‐inf POC (5‐year OS 31.8% vs 51.6%; P = .05 and 5‐year DFS 13.6% vs 31.9%; P = .04) and with No‐POC (5‐year OS 29.4% vs 58.7%; P = .03 and 5‐year DFS 11.8% vs 39.7%; P = .03). There were no differences between Non‐inf POC and No‐POC patients. POC severity calculated using the Comprehensive Complications Index did not influence OS and DFS before and after PSM. Conclusion The negative oncological impact of POCs after CRLM resection is determined by infective etiology not by severity.

BackgroundPatients with rheumatoid arthritis (RA) have a significantly increased risk for cardiovascular (CV) morbidity and mortality when compared to general population. Traditional risk factors do not explain the increased CV risk, which appears to be linked to chronic inflammation.1 The leading cause of death in RA-patients is atherosclerotic cardiovascular disease (ASCVD).2 Carotid artery evaluation by ultrasound is a useful tool for the detection of subclinical atherosclerosis. The presence of increased carotid intima-media thickness (CIMT) significantly raises the risk of ASCVD, mainly stroke and myocardial infarction.3 ObjectivesTo compare CIMT between Mexican-mestizo RA-patients and matched controls.MethodsDesign: observational, cross-sectional, case-control study. Patients 40 to 75 years old who fulfilled the 2010 ACR/EULAR and/or the 1987 ACR classification criteria for RA were consecutively enrolled. Patients with previous ASCVD or any other rheumatic disease were excluded. Carotid artery wall hypertrophy (CAWH) was defined as a CIMT≥0.9 and<1.2 mm whereas carotid plaque (CP) was defined as a CIMT≥1.2 mm or a≥50% focal increase of CIMT compared to the surrounding wall.ResultsA total of 100 RA-patients and 49 matched control subjects were included in the final analysis. Their characteristics are shown in Figure 1. RA-patients had a median disease duration of 10.3 years and a median DAS-28–CRP of 3.2. Regarding carotid ultrasound findings, there was a significant difference in CAWH and average CIMT between groups (p<0.001).Abstract AB1291 – Figure 1Demographic CharacteristicsSD: Standard deviation, DM2: Type 2 diabetes mellitus, CAWH: Carotid artery wall hypertrophy, CIMT: Carotid intima-media thickness.ConclusionsThere was significantly increased CIMT and presence of CAWH in RA-patients compared to matched controls. These findings might be major contributors to the increased CV morbidity and mortality of RA-patients. Further research is needed to determine the relationship between RA-specific factors such as disease duration and activity and the presence and magnitude of carotid ultrasound abnormalities.References[1] Galarza-Delgado DA, Azpiri-Lopez JR, Colunga-Pedraza IJ, Cardenas-de la Garza JA, Vera-Pineda R, Garcia-Colunga JI, et al. Comparison of statin eligibility according to the Adult Treatment Panel III, ACC/AHA blood cholesterol guideline, and presence of carotid plaque by ultrasound in Mexican mestizo patients with rheumatoid arthritis. Clin Rheumatol. 2016;35(11):2823–7.[2] Avina-Zubieta JA, Thomas J, Sadatsafavi M, Lehman AJ, Lacaille D. Risk of incident cardiovascular events in patients with rheumatoid arthritis: a meta-analysis of observational studies. Annals of the rheumatic diseases. 2012;71(9):1524–9.[3] Agca R, Heslinga SC, Rollefstad S, Heslinga M, McInnes IB, Peters MJ, et al. EULAR recommendations for cardiovascular disease risk management in patients with rheumatoid arthritis and other forms of inflammatory joint disorders: 2015/2016 update. Annals of the rheumatic diseases. 2017;...

BackgroundTuberculosis (TB) represents a major global health problem. TB has a higher incidence among patients with autoimmune rheumatic diseases than in the general population. The incidence and severity of TB in patients with systemic lupus erythematosus (SLE) varies greatly among different series (2.5–13.8%).ObjectivesTo investigate the frequency and characteristics of TB in Mexican mestizo patients with SLE.MethodsWe reviewed the charts of 123 patients with SLE in our lupus clinic. Patients who developed TB after the diagnosis of SLE were identified. Data of all SLE patients followed up in our clinic were retrospectively analyzed. Clinical and demographic characteristics and treatment before diagnosis of TB were recorded.ResultsA total of 123 SLE patients were analyzed, 89.43% (n=110) woman. Seven cases (5.69%) of TB infection developed after the diagnosis of SLE. Pulmonary TB was reported in 3 patients (2.44%). Extra-pulmonary TB infecction was reported in 3 (2.44%) patients (one case of tuberculous pleurisy, one case of meningeal TB, and 1 case of cutaneous TB). Also, we found 1 SLE patient (0.81%) with latent TB infection. All patients had good response to treatment. No one received biologic therapy at the time of the diagnosis of TB infection. We did not found any case of disseminated infection or mortality related to TB infection.ConclusionsThese results suggest that in a country with high TB burden, TB screening and treatment of latent TB would be useful since the diagnosis of SLE is made.ReferencesErdozain, J. G., Ruiz-Irastorza, G., Egurbide, M. V., Martinez-Berriotxoa, A., & Aguirre, C. (2006). High risk of tuberculosis in systemic lupus erythematosus? Lupus, 15(4), 232–235.Disclosure of InterestNone declared

El carácter vernáculo ancestral y cotidiano de Tlacotalpan Carlos Lira VásquezTeoría: Una revisión de las principales corriente teóricas sobre el análisis urbano Sergio Tamayo Flores-Alatorre Desarrollo: Reestructuación económica y cambios en l a especialización urbana: los casos de Guadalajara y Monterrey (1 980-1 988)