HighlightsMammary analog secretory carcinoma (MASC) is a newly described carcinoma of the salivary glands.MASC is characterized by morphologic and immunohistochemical features that strongly resemble a secretory carcinoma (SC) of the breast.MASC and SC of the breast share the presence of translocation t(12;15) (p13;q25), that results in the formation of an oncogenic fusion gene ETV6-NTK3.The majority of MASC present among men and arise from the parotid gland.MASC is a low-grade carcinoma with potential for high-grade transformation.

HighlightsCarotid body tumors are rare neuroendocrine neoplasms derived from neural crest cells.MRI imaging is considered to be the gold standard criterion for carotid body tumors diagnosis.Surgical resection of carotid body tumors represents a special challenge to the surgeon.

HighlightsExtraskeletal myxoid chondrosarcoma (EMC) is a rare tumor characterized by the multinodular growth of primitive chondroid cells in an abundant myxoid matrix.EMC is categorized as a tumor of uncertain differentiation by the 2002 WHO classification.EMC has shown to have the recurrent balanced chromosomal translocation t(9;22) (q22;q12.2), which leads to the oncogenic fusion gene EWSR1-NR4A3.EMC usually presents in male patients beyond their fifth decade as a slow growing, palpable mass in the extremities.Pulmonary extraskeletal myxoid chondrosarcomas are extremely rare with only isolated case reports found in the literature.

Background: Anal canal cancer is an uncommon cancer worldwide; nevertheless its incidence has risen in recent years. Squamous carcinoma is the most common histological type of anal canal cancer. The most important risk factor for squamous anal carcinoma is infection by oncogenic types of human papillomavirus. The clinical presentation for this malignancy usually includes pain, bleeding, swelling, pruritus, and discharge. The treatment goals for anal cancer include local control, ideally with sphincter preservation. The management of this malignancy has evolved from surgery to curative chemoradiation, with radical surgery as a salvage treatment.Case report: A 53-year-old female patient presented to the emergency department with severe pain localized to the perineal area, associated with transanal bleeding, purulent drainage, fever, and the sensation of a bulge near the anus. Proctological exploration showed a left lateral swelling with erythema and a secondary opening with haemopurulent drainage, digital rectal examination revealed a left lateral mass with minimal fluctuation. A rectal exam under anesthesia was performed identifying an ulcerated mass with an associated abscess and fistulous tract. Biopsies of the indurated ulcer with rolled up borders were obtained. The pathology report revealed an invasive squamous carcinoma. We performed a CT-scan to classify the tumor as T3N0MO corresponding to NCCN clinical stage II. Serology for HIV was negative. Biopsy samples were negative for HPV infection. The patient underwent chemoradiation with Mitomycin C and Capecitabine with complete clinical response.

No abstract