In the RENAL study, a negative mean daily fluid balance was consistently associated with improved clinical outcomes. Fluid balance may be a target for specific manipulation in future interventional trials of critically ill patients receiving renal replacement therapy.

Both of these provisional biomarkers of colon cancer underwent accelerated improvement at 6 months with folate supplementation. However, these markers also improved with placebo at 1 yr. Therefore, potential confounding factors that seem to modulate these biomarkers need to be identified and corrected in order for these markers to serve as suitable surrogate endpoints in folate chemoprevention trials.

We solve the inverse problem of deblurring a pixelized image of Jupiter using regularized deconvolution and by sample-based Bayesian inference. By efficiently sampling the marginal posterior distribution for hyperparameters, then the full conditional for the deblurred image, we find that we can evaluate the posterior mean faster than regularized inversion, when selection of the regularizing parameter is considered. To our knowledge, this is the first demonstration of sampling and inference that takes less compute time than regularized inversion in an inverse problems. Comparison to random-walk Metropolis-Hastings and block Gibbs MCMC shows that marginal then conditional sampling also outperforms these more common sampling algorithms, having better scaling with problem size. When problem-specific computations are feasible the asymptotic cost of an independent sample is one linear solve, implying that sample-based Bayesian inference may be performed directly over function spaces, when that limit exists.1 A classification of Bayesian image representations and prior models as low-level, intermediate-level, and high-level is given in [19].

Background: Estimates of habitual dietary folate intake are known to be imprecisely correlated with systemic measures of folate status. Furthermore, measurements of blood folate concentrations may not accurately reflect the concentration of folate in tissues of interest. This issue is important for assessing folate status in the colorectal mucosa because low dietary intake or blood concentrations of folate are associated with an increased risk of colorectal neoplasia. Objective: We examined whether conventional measures of folate in blood and a more sensitive, inverse indicator of systemic folate status, serum homocysteine, accurately reflected folate concentrations in human colonic mucosa obtained by endoscopic biopsy. Design: In 30 persons with colorectal polyps, blood samples were taken and biopsies of normal rectosigmoid mucosa performed at the time of colonoscopic polypectomy. Serum, red blood cell, and colonic mucosal folate and serum homocysteine concentrations were measured. Results: Serum and red blood cell folate and serum homocysteine concentrations accurately reflected colonic mucosal folate concentrations; among these, serum homocysteine correlated best with mucosal concentrations. Folate concentrations in the normal rectosigmoid mucosa were significantly lower in persons with adenomatous polyps than in those with hyperplastic polyps (P = 0.04). Conventional measures of systemic folate status were not significantly lower in those with adenomas, although serum homocysteine was mildly elevated (P = 0.04). Conclusions: Our data underscore the ability of systemic measures of folate status, particularly serum homocysteine, to reflect folate concentrations in the colonic mucosa. Nevertheless, future studies that examine the ability of folate to modulate colorectal carcinogenesis may benefit from direct measurement of folate in the colon.Am J Clin Nutr 1998;68:866-72.