tion. Further investigation of the dealkylation products, namely the chlorinated and hydroxylated 4,6-diamino-striazines, was hindered by extraction and partition difficulties but is in progress.

Four calves were fed polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans for 120 days at levels somewhat higher than what may be found in forage near some waste incinerators and manufacturing plants. Four calves were fed identical diets but without the chemicals. Using bioelectrical impedance measurements of total body fat, 30-50% of the dosed 2,3,7,8-TCDD, 1,2,3,7,8-PeCDD, and 2,3,4,7,8-PeCDF was estimated to be retained by the animals. Although these same congeners were bioconcentrated in adipose tissue (BCF approximately 10), consumer products such as ribeye showed concentrations less than what were found in the animal feed (BCF approximately 0.1). Distribution of the dioxins and furans into various lipid compartments appeared to be rather uniform in back fat, perirenal fat, and ribeye for tetra to hexa congeners. Ribeye, serum, and liver lipids had higher concentrations of the higher chlorinated congeners, due in part to not reaching a steady state. An unexpected source of dioxin and furan contamination was discovered during the experiment, resulting in the control animals having concentrations of some congeners that were equal to or in some cases greater than those of the dosed animals. Pentachlorophenol-treated wood components in the pole barn where the feeding experiment was conducted were found to have contributed to the animals' exposure.

No abstract

Rats and milking goats were given a single dose of either p-chlorophenyl-14C(U) /V-methylcarbamate (ring-label) or p-chlorophenyl /V-methylcarbamate-14C (carbonyl-label). Expiratory gases contained carbon-14 after the carbonyl-labeled compound was given but not after the ring-labeled compound was given. Most of the carbon-14 administered as the ring-labeled compound was excreted in the urine, with only trace amounts in the feces. Milk

The following compounds were identified in rat feces following a single oral dose of , '-DDT-14C: , '-DDD, , '-DDT, 3-hydroxy-2,4'-DDD, 3-hydroxy-2,4'-DDT, 4-hydroxy-3-methoxy-2,4'-DDD, 4-hydroxy-3-methoxy-2,4'-DDT, , '-DDA, 3-hydroxy-2,4'-DDA, 4-hydroxy-3-methoxy-2,4'-DDA, glycine conjugate of , '-DDA, o,p'-dichlorobenzhydrol, serine conjugate of , '-DDA, 4-hydroxy-2,4'-DDA, and 5-hydroxy-2,4'-DDA. o,p'-