We examined the reservoir potential of white-tailed deer for Anaplasma phagocytophilum. Results suggest that white-tailed deer harbor a variant strain not associated with human infection, but contrary to published reports, white-tailed deer are not a reservoir for strains that cause human disease. These results will affect surveillance studies of vector and reservoir populations.

No abstract

In previous studies we have shown that AKR mice could be protected from spontaneous leukemia by specific immunotherapy in combination with splenectomy. In this experiment we investigated the effects of nonspecific immunotherapy with C. parvum in a similar regimen. It was found that bi-weekly, ip inoculations of 0.7 mg of C. parvum could significantly protect AKR mice from spontaneous tumors, and that splenectomy could not modify this effect. Thus, the spleen does not appear to play a determinant role in mediating the protective effects of C. parvum, as had been suggested in other systems.

No abstract