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When Evans blue is injected into the circulation of normal individuals a constant dye concentration is reached within 20 min. and this concentration is maintained for a further 40 min. Subsequently it diminishes at a rate of about 5 % per hour [Crooke & Morris, 1942]. In the course of investigations uponi the plasma volume in patients with shock, however, unaccountable alterations in the concentration of dye were sometimes found. A systematic examination of the factors which might be responsible for such anomalous dye concentration curves has therefore been made.At first the anomalous results were thought to be associated with shock, but this was disproved by a normal curve occurring in a patient with severe traumatic shock, and whose systolic blood 1 30-pressure was consistently below 60 mm.a Hg (Fig. 1 a). In contrast to this, a e moderately shocked patient with second 1 40-X and third degree burns of the hands and g l30-face, whose systolic blood pressure variedfrom 140 to 150mm. Hg, had an anomalous g 1 20-O curve (Fig. 1b).

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