Prevalensi obesitas dari tahun ke tahun mengalami peningkatan yang dapat membahayakan kesehatan terutama penyakit cardiovascular yang ditandai dengan peningkatan Indeks Massa Tubuh (IMT) dan kadar kolesterol. Tujuan penelitian adalah untuk mengetahui pengaruh senam aerobik intensitas sedang terhadap penurunan Indeks Massa Tubuh dan kadar total kolesterol pada wanita penderita obesitas. Jenis penelitian adalah penelitian eksperimental semu dengan rancangan penelitian one group pretest postets design. Sampel penelitian berjumlah 10 orang yang sudah memenuhi kriteria. Senam aerobik dilakukan selama satu bulan, 3 kali seminggu, waktu 50 menit dengan target denyut jantung 60-70% MHR. Pengukuran IMT dan kolesterol total dilakukan sebelum dimulai program latihan dan setelah dan setelah menjalani program latihan senam aerobik. Hasil penelitian diperoleh IMT dan kadar kolesterol total pretest adalah 39,61 kg/m2 dan 191,1 mg/dl. Kadar IMT  dan kadar kolesterol total postest adalah 24,81 kg/m2 dan 154mg/dl. Hasil uji statistika menunjukkan terdapat perbedaan IMT dan kadar total kolesterol pretest dan postest. Kesimpulan penelitian adalah senam aerobik intensitas sedang dapat menurunkan IMT dan kadar kolesterol total pada wanita penderita obesitas.Kata kunci: Senam aerobik, Intensitas sedang, Indeks massa tubuh, Kolesterol

BACKGROUND: Mangosteen (Garcinia mangostana L.) rind had been known as an agriculture waste. However, some recent studies reported that Mangosteen rind had some health benefit. The rind (skin) of Mangosteen fruit was reported to contain compounds such as xanthones and anthocyanin antioxidants. There is a need to examine the chemical compound content of Mangosteen rind and the activities of antioxidants contained in the Mangosteen rind, so as to increase natural source of antioxidants for human health. This study aimed to produce ethanol extract of Mangosteen rind, to identify chemical compound content, and test its antioxidant activity. SUBJECT AND METHODS: Ethanol extract of Mangosteen rind was produced to identify its chemical compound content. The DPPH method was used to test Mangosteen's antioxidant activity with EC50 as a measure of the fruit potency. Half maximal effective concentration (EC50) refers to the concentration of Mangosteen fruit which induces a response halfway between the baseline and maximum states after a specified exposure time. The EC50 of Mangosteen and vitamin C were compared. RESULTS: Mangosteen rind extract consisted of saponin, tannins, polyphenol, triterpenoid, flavonoid, alkaloid and glycoside. The DPPH test of antioxidant activity showed that the EC50 of Mangosteen was 8.85 µg/ml, which exceeded the EC50 of 4.55 µg/ml in vitamin C. CONCLUSION: Mangosteen rind extract consisted of saponin, tannin, polyphenol, triterpenoid, flavonoid, alkaloid and glycoside. Mangosteen rind extract has a strong antioxidant activity.

Aktivitas fisik berat maupun  olahraga aerobik dapat meningkatkan konsumsi oksigen dalam tubuh 10-20 kali  dan 100-200 kali lipat pada otot. Peningkatan penggunaan oksigen akibat peningkatan aktifitas dapat meningkatkan produksi radikal yang dapat mempengaruhi performance atlet ditandai dengan turunnya Hb. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pemberian vitamin E terhadap kadar hemoglobin pada aktifitas fisik maksimal mahasiswa Ilmu Keolahragaan FIK Unimed.Jenis penelitian yang dilakukan adalah penelitian eksperimental semu dengan rancangan penelitian Randomized Control Group Pretest-Postest Design. Penelitian dilaksanakan di Stadion  Sepakbola dan Laboratorium Fisiologi FIK UNIMED. Penelitian dilakukan selama 2 bulan dengan populasi dan sampel mahasiswa Ilmu Keolahragaan yang memenuhi kriteria. Pada penelitian ini akan diukur kadar Haemoglobin sebelum dan sesudah mengkonsumsi Vitamin E dengan dosis 400mg setelah melakukan aktifitas fisik maksimalDari hasil analisis data diperoleh bahwa pemberian Vitamin E dengan dosis 400mg dapat mencegah penurunan kadar Haemoglobin pada mahasiswa Ilmu Keolahragaan FIK Unimed. Kata Kunci: vitamin E, radikal bebas, haemoglobin, aktiftas fisik maksimal

Dyslipidemia and sedentary lifestyle are risk factors for atherosclerotic heart disease. The research objective was to determine the effect of aerobic exercise and virgin coconut oil supplementation on the lipid profile of obese women. The research subjects were 20 women with obesity, divided into two groups, namely the experimental group (doing aerobic exercise and VCO supplementation) and the control group (only doing aerobic exercise) with the 43.55±2.21 age, 154.75±0.05 height, 75.75±1.44 weight and 31.69±1.63 BMI. The experimental group did aerobic exercise and VCO supplementation for 8 weeks, while the control group did aerobic exercise without VCO supplementation. Total cholesterol and triglyceride levels were measured before and after aerobic exercise. Using the t test, statistical analysis was conducted and the significance level of the test was considered to be p<0.05. The results showed that the combination of aerobic exercise with VCO supplementation resulted in a more significant reduction in triglyceride levels and cholesterol compared to aerobic exercise (p = 0.001). The conclusion is that the combination of aerobic exercise with VCO supplementation can reduce triglyceride levels and total cholesterol, thus preventing cardiovascular disease.

BACKGROUND: Living cells continuously produce free radicals and reactive oxygen species (ROS) as a part of metabolic processes. These free radicals are neutralized by an antioxidant defense system. Maximal physical activity can produce an imbalance between ROS and antioxidants and thus may cause oxidative stress, which is possibly related to fatigue and tissue injury. Red fruit oil contains high beta-carotene and tocopherol as antioxidants which could overcome oxidative stress condition. AIM: The aim of this study was to determine the effect of red fruit oil on exercise endurance and oxidative stress in rats at a maximal physical activity. METHODS: Twenty-four male rats were divided into four groups. The control group (I) was administered with 1.5 ml distilled water, intervention groups (II), (III), and (IV) were administered with different doses of red fruit oil (0.15 ml/kgBW, 0.3 ml/kgBW, and 0.6 ml/kgBW, respectively). All groups were trained to swim for 4 weeks and then were forced to swim without a load until being exhausted. The malondialdehyde (MDA), glutathione peroxidase (GPx) levels, and time of swimming to exhaustion were measured in all groups. RESULT: The results showed that MDA level obtained was decreasing significantly (p < 0.05), GPx and time of swimming were increasing significantly (p < 0.05) in the intervention groups. CONCLUSION: The results suggest that red fruit oil can obviously reduce MDA level, increased GPx, and endurance and delay fatigue induced by maximal physical activity in the rat.