Diabetic wound healing is a complicated procedure because hyperglycemia changes the various stages of wound healing. In type 2 diabetes mellitus (T2DM), oxidative stress is proven to be a critical factor in causing non-healing wounds and aggravating the inflammatory phase, resulting in the amputation of lower limbs in T2DM patients. This makes scientists figure out how to control oxidative stress and chronic inflammation at the molecular level. Nuclear factor erythroid 2- related factor 2 (Nrf2) releases antioxidant proteins to suppress reactive oxygen species (ROS) activation and inflammation. The current review discusses the role of Nrf2 in improving diabetic wound healing by reducing the production of ROS and thus reducing oxidative stress, as well as inhibiting nuclear factor kappa B (NF-kB) dissociation and nuclear translocation, which prevents the release of inflammatory mediators and increases antioxidant protein levels, thereby improving diabetic wound healing. As a result, the researcher will be able to find a more effective diabetic wound healing therapy.

magnified imageA solventless parallel synthesis of some novel, N‐substituted dihydropyridines by the application of microwaves is reported. The synthetic methodology adopted to synthesize the titled compounds and their antioxidant activity is described. J. Heterocyclic Chem., 46, 336 (2009).

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Wound healing is a complicated organised process that includes numerous phases that connect diverse cellular events and activate several intracellular molecular pathways in injured cells and tissues. Delay in wound healing owing to high levels of oxidative stress is a major difficulty in various metabolic illnesses, including diabetes mellitus. Several therapeutic wound dressing materials and methods, such as hyperbaric oxygen treatment and negative pressure wound therapy, have been developed to speed up wound healing and restore cellular homeostasis. A significant advance has been made in locating transcriptional regulators involved in wound healing. The redox sensitive transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) is the major regulator of antioxidant defense regulation, inducing the expression of cyto-protective genes and increasing the generation of antioxidants that scavenge free radicals.Activators of Nrf2 have been shown to reduce oxidative stress and improve wound healing in a variety of pathophysiological situations, including diabetes and its consequences such as diabetic foot ulcers, chronic kidney disease, and diabetic nephropathy. Several therapeutic chemicals have been discovered to alleviate oxidative stress and consequently increase cell proliferation. Angiogenesis results in tissue healing through activating the transcription factor Nrf2. This review focuses on role of Nrf2 mediated antioxidant gene expression for diabetic wound healing.

Pyridine derivatives R 0380 Facile, Microwave-Assisted Parallel Syntheses of N-Substituted 1,4-Dihydropyridines of Biological Interest. -6 Title compounds of type (V) are prepared. Compounds (Vb) and (Vc) are found to possess significant antioxidant activities [for intermediates (III) no yields given]. -(KUMAR*, B. R. P.; MASIH, P.; LUKOSE, C. R.; ABRAHAM, N.; PRIYA, D.; XAVIER, R. M.; SAJI, K.; ADHIKARY, L.; J.