Cancer mortality
is increasing at an alarming rate across
the globe.
Albeit, many therapeutics are available commercially, they are not
effective and have no cure up to today. Moreover, the knowledge gap
in cancer therapy persists, representing a potential blind spot for
the innovation of effective anticancer therapeutics. This review presents
an update on current advancements in nanopeptide therapeutics. Herein,
a detailed exploration of peptide-functionalized nanoparticles for
the development of nanotherapeutics was carried out. Different approaches
that include self-assembly nanostructures, solid phase peptide synthesis,
ligand exchange, chemical reduction, and conjugation methods for assembling
peptides for functionalizing nanodrugs are also highlighted. An outlook
on biomedical applications is also reviewed. Additionally, a comprehensive
discussion on targeted cancer cell therapy and mechanism of action
are provided. The present review reflects the functional novelty of
nanodrugs to improve stability, accessibility, bioavailability, and
specificity toward cancerous cells. Finally, it summarizes the current
challenges and future perspectives on the formulation of these nanodrugs.
Due to the ongoing industrial revolution, solar-driven water splitting and pesticide degradation are highly sought to cope with catastrophes such as depleting fossil reservoirs, global warming, environmental degradation and others....
Advances in nanotechnology
over the past decade have emerged as
a substitute for conventional therapies and have facilitated the development
of economically viable biosensors. Next-generation biosensors can
play a significant role in curbing the spread of various viruses,
including HCoV-2, and controlling morbidity and mortality. Pertaining
to the impact of the current pandemic, there is a need for point-of-care
biosensor-based testing as a detection method to accelerate the detection
process. Integrating biosensors with nanostructures could be a substitute
for ultrasensitive label-free biosensors to amplify sensing and miniaturization.
Notably, next-generation biosensors could expedite the detection process.
An elaborate description of various types of functionalized nanomaterials
and their synthetic aspects is presented. The utility of the functionalized
nanostructured materials for fabricating nanobiosensors to detect
several types of viral infections is described in this review. This
review also discusses the choice of appropriate nanomaterials, as
well as challenges and opportunities in the field of nanobiosensors.
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