Steven Johnson Syndrome (SJS) or Toxic Epidermal Necrolysis (TEN) is a life threatening immune complex mediated hypersensitivity reaction which mainly involves skin and mucous membrane. SJS is generally induced by the drugs. The manifestations include blisters on skin, facial swelling and hyper pigmentation. Here is a 28-yearold Indian male received Ofloxacin, Paracetamol and Phenobarbitone and experienced a severe skin reaction which was diagnosed as Stevens Johnson syndrome (SJS). The above drugs will be implicated in cases of Stevens Johnson Syndrome (SJS) / Toxic Epidermal Necrosis (TEN). There are few case reports of that have been associated with Stevens Johnson Syndrome (SJS)/ Toxic Epidermal Necrosis (TEN). We hope that this case report creates awareness to the health care professionals.

Amongst antibiotics, amoxicillin is oftentimes prescribed to oppugn array of infections. Penicllins are well recognised for their drug induced cutaneous eruptions substantially in paediatric population. This case is being promulgated to strengthen the evidence against amoxicillin induced skin reactions.