Background: Breast cancer is the most common cancer among women, affecting 2.1 million women every year. Assessment of quality of life is considered the most important and strong indicator for breast cancer outcomes. The purpose of this study was to analyze biopsychosocial factors that affect the quality of life of breast cancer patients. Subjects and Method: A cross-sectional study was conducted in the breast cancer community in Surakarta, Central Java from December 2019 to January 2020. A sample of 200 breast cancer patients was selected by simple random sampling. The dependent variable was the quality of life of breast cancer patients. The independent variables were stadium, chemotherapy, length of diagnosis, age, depression, coping strategies, social networks, level of knowledge, education level, income level, employment status, and marital status. Quality of life was measured by WHO-QOL-BREF. Other data were collected by questionnaire. Data were analyzed by path analysis using the Stata 13 application.Results: The quality of life of breast cancer patients was directly increased by high family income (b= 3.27; 95% CI= 1.67 to 4.87; p<0.001), strong social network (b= 2.61; 95%CI= 0.96 to 4.26; p= 0.002), length of diagnosis ≥24 months (b= 2.68; 95% CI= 0.98 to 4.39; p= 0.002), good coping strategy (b= 1.65; 95% CI= 0.12 to 3.19; p= 0.034), and finished chemotherapy (b=1.32; 95% CI = -0. 22 to 2.87; p= 0.093). The quality of life of breast cancer patients was directly decreased by depression (b= -2.78; 95% CI=-4.41 to -1.15; p= 0.001) and advanced stage (b=-2.43; 95% CI= -4.04 to 0.83; p= 0.003). Quality of life was indirectly affected by coping strategy, marital status, chemotherapy, knowledge, length of diagnosis, age, employment, and education. Conclusion:The quality of life of breast cancer patients is directly increased by high family income, strong social network, length of diagnosis ≥24 months, good coping strategy, and finished chemotherapy. The quality of life of breast cancer patients is directly decreased by depression and advanced stage. Quality of life is indirectly affected by coping strategy, marital status, chemotherapy, knowledge, length of diagnosis, age, employment, and education.

Background: A cancer diagnosis and its treatment can be expensive. So that cancer patients may suffer from mental and physical problems. Quality of life (QOL) is a major concern of patients with terminal cancer. This study aimed to investigate the biopsychosocial determinants of quality of life in patients with breast cancer. Subjects and Method: This was a cross sectional study. A sample of 200 patients with breast cancer was selected by a simple random sampling. The dependent variable was quality of life. The independent variables were age, marital status, stage of cancer, chemotherapy, length of disease, coping strategy, family income, and modal social. Quality of life was measured by WHO-QOL-BREF. The other variables were collected by a questionnaire. The data were analyzed by a multiple logistic regression run on Stata 13. Results: Strong modal social (b= 2.52; 95% CI= 0.82 to 4.22; p= 0.003), complete chemotherapy (b= 1.65; 95% CI= -0.05 to 3.35; p= 0.057), length of diagnosis ≥24 months (b= 2.39; 95% CI= 0.69 to 4.22; p= 0.006), family income ≥Rp 5,600,000 (b= 2.94; 95% CI= 1.24 to 4.64; p= 0.001), and good coping strategy (b= 1.70; 95% CI= 0.11 to 3.29; p= 0.036) increased quality of life of patients with breast cancer. Late stage of cancer (b= -2.09; 95% CI= -3.78 to -0.40; p= 0.015) and depression (b= -2.48; 95% CI= -4.26 to -0.69; p= 0.001) decreased quality of life of patients with breast cancer. Age decreased quality of life (b= -0.87; 95% CI= -2.94 to 2.77; p= 0.952), but it was statistically non-significant. Marital status increased quality of life (b= 1.32; 95% CI= -0.35 to 2.99; p= 0.123), but it was statistically non-significant. Conclusion: Strong modal social, complete chemotherapy, length of diagnosis ≥24 months, family income ≥Rp 5,600,000, and good coping strategy increase quality of life of patients with breast cancer. Late stage of cancer and depression decrease quality of life of patients with breast cancer. Age decreases quality of life, but it is statistically non-significant. Marital status increased quality of life, but it is statistically non-significant. Keywords: quality of life, breast cancer Correspondence: Rizka Amalia Dewi. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta, Central Java 57126, Indonesia. Email: drizkaez@gmail.com. Mobile: +6282313121768. DOI: https://doi.org/10.26911/the7thicph.01.47