Background: Urothelial (transitional cell) bladder carcinoma UBC is the most common malignancy of the urinary tract and the seventh leading cancer in men worldwide. Mutations in P53 gene are the most common genetic abnormality inhuman cancer. Mutation of P53 gene results P53protein accumulation in cells' nuclei. This accumulation is detectable with Immunohistochemical methods and correlates with P53 gene mutation. Aims: The study aimed to detect the expression of p53 in Urothelium cell carcinoma of urinary bladder using Immunohistochemical method, and correlate the expression of p53 with the gender, age of patient and histological grade. Methods: Forty paraffin embedded blocks previously diagnosed as transitional cell carcinoma were collected. This retrospective analytical study conducted at,
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