We determined the concentrations of manganese in whole blood and hair in 52 epileptics, 6 blood relatives, and 24 normal controls. Blood, and possibly hair manganese content, was significantly lower in treated epileptics than in controls (p less than 0.002). Although not all patients showed reduced tissue manganese levels, most of those with frequent seizures had manganese levels falling below the lowest control level, suggesting a relationship between manganese tissue levels and high seizure activity. These differences in manganese levels were not correlated with the type, dose, or plasma levels of anticonvulsant medication. Reduced manganese availability at the neuronal level, where Mn++ stabilizes membrane excitability, may affect epileptogenic lesions to increase the likelihood of seizure activity.

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Kethoxal inhibited cell division of E. coli (strain K-12), and that glutamic acid antagonized inhibition. Glutamic acid similarly antagonized the action of Kethoxal-bisulphite complex in tumor-bearing animal experiments. 12Egyftd, L. G., to be published elsewhere. HYDROXYLYSINE FORMA TION FROM LYSINE DURING COLLAGEN BIOSYNTHESIS*

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