In 1994, a 117‐ha wetland was designed, constructed, and operated by the Tulare Lake Drainage District (TLDD), California, USA, to provide foraging and nesting habitat for American avocets (Recurvirostra americana) and black‐necked stilts (Himantopus mexicanus). The wetland was operated seasonally in compliance with regulatory requirements to compensate for impacts to stilts, avocets, and other wildlife exposed to elevated selenium concentrations, fluctuating water levels resulting in nest flooding, and high nest‐predation rates at the TLDD agricultural drainage evaporation basins. Water supply for the wetland was from low‐selenium (typically <2 μg/L) saline agricultural drainage water, although the facility also had capability to blend and use freshwater and saline supplies. Coincident with wetland construction, 2 evaporation basins totaling 1,174 ha were physically modified and operated to discourage their use by shorebirds. In the first year of wetland operation (1995), American avocet and black‐necked stilt nest construction at the wetland was 17.6 nests/ha. This compares to a preproject (1994) combined density of 1.9 nests/ha at the evaporation basins. From 1995 through 2004, annual nesting attempts by American avocets and black‐necked stilts at the wetland averaged 2,896 per year (24.8 nests/ha). American avocets and black‐necked stilts represented 91% of the nests observed at the wetland. Over the 10‐year monitoring period, nest success at the wetland averaged 82% for American avocets and 75% for black‐necked stilts. We estimated nest predation rates at the constructed wetland to be <1%. During the same period, American avocet and black‐necked stilt nesting at the evaporation basins declined from 2,266 in 1994 to 9 in 2004. The constructed wetland has proven to be effective in attracting and providing suitable nesting habitat for large numbers of avocets and stilts. Results of this long‐term study confirm the validity of management recommendations for American avocets and black‐necked stilts and suggest that agricultural drainage can be successfully managed to provide highly productive managed wetlands.

Zomepirac sodium (ZS) (5 mg/kg i.v.) was used to evaluate the effects of preischemia cyclooxygenase inhibition on CBF (as assessed by 133Xe clearance), CBF–PaCO2 responsiveness, and electrophysiologic (EEG) parameters before and after a 15-min period of complete global ischemia produced by four-vessel occlusion and mild hypotension. During the 15-min period of ischemia, CBF was essentially zero. Following reflow all groups displayed an initial hyperemia as compared with control (92 ± 11 vs. 141–146 ml/100 g/min). Saline-treated animals during reflow displayed a delayed hypoperfusion (26 ± 3 ml/100 g/min), which showed no improvement during the 2-h reflow period prior to death. In contrast, ZS-treated animals during reflow displayed significantly higher flows during the hypoperfusion phase (72 ± 9 ml/100 g/min). The CBF–PaCO2 response displayed an approximately sevenfold reduction in slope at 2 h after reflow in saline-treated animals. This decrease in PaCO2 reactivity was not observed in the ZS-pretreated animals. With regard to EEG, all animals showed a total flattening during the 15 min of ischemia. In saline-treated animals only one of seven showed any sign of even marginal recovery. In ZS-treated animals EEG activity showed prominent recovery in seven of seven. Brainstem auditory evoked potentials were monitored and showed prominent recovery of amplitude and latency in ZS but not saline-treated animals during reflow.

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