The objective of this study was to determine the contrlbutlon of renal nerves to the enhanced afferent arterlolar reactivity observed m anglotensm II (Ang II)-induced hypertension Unmephrectomlzed Sprague-Dawley rat3 were divided mto four groups sham rats, renal-denervated rats, Ang II-Infused (at 40 nglmm for 13 days) rats, and Ang II-mfused+renal-denervated rats With the use of an Implanted arterial catheter, mean arterial pressure (MAP) was momtored m conscious rats Ang II Infusion resulted m a progressive increase In MAP from 982 I (day 0) to 16627 mm Hg (day 13) This Increase In MAP was attenuated tn denervated rats and averaged 136?3 mm Hg on day 13 Kidneys were harvested on day 13 for mlcloclrculatory expenments or measurement of mtrarenal Ang II levels Basal afferent arterlolar diameter was similar in all groups, and group averages ranged from 19 6 to 20 7 pm Chrome Ang II Infusion increased mtrarenal Ang II levels Renal denervatlon did not alter this effect Increasing perfusion pressure from 100 to 160 mm Hg reduced afferent artermlar diameter slgnlficantly by I I 250 6% m the sham group and by a similar degree m the remaining three groups Superfusion with Ang II (10 nmol/L) reduced afferent arterlolar diameter by 34 3+2 0% m the sham group This response was enhanced m Ang II-Infused (62 353 4%) but not in renal-denervated or Ang II-mfused+renal-denervated rats Addmonally, the enhanced afferent arteriolar reactivity to Ang II wa$ not Influenced by adrenerglc receptor blockade The afferent artenolar response to noreplnephrme wa? enhanced m renal-denervated, Ang II-infused, and Ang II-mtused+renal-denervated rats compared with sham controls Admmlstratlon of the calcium lonophore A23187 decreased afferent arterlolal diameter slmllarly m all four groups These results indicate that renal nerves contribute to the development of hypertension and to the enhanced afferent artellolar responsiveness to Ang II ehclted by chronic Ang II mfu\lon (Hypertenwn. 1997;29[part 2]:442-449.)

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Purdtie Uniue rs it y , Lafa yette , Ind.The anion derived from a n aliphatic nitro compound is capable of covalency formation at either carbon o r oxygen; i.e., it i s a n ambident anion.

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