Objetivo:identificar sistematicamente a efetividade do uso tópico da própolis verde no processo de cicatrização de feridas cirúrgicas. Método: revisão sistemática da literatura que considerou as publicações disponíveis nas bases de dados National Library of Medicine (PubMed/Medline), Latin American and Caribbean Health Sciences Literature(LILACS), The Cumulative Index to Nursing and Allied Health Literature (CINAHL) e Web of Science. O risco de viés dos estudos foi analisado por meio da ferramenta Systematic Review Centre for Laboratory animal Experimentation(SYRCLE). Resultados: os quatro estudos analisados utilizaram a própolis verde para a cicatrização de lesões confeccionadas cirurgicamente. Todos os estudos selecionados foram de metodologia experimental, realizados com animais. Dois estudos (50%) utilizaram o extrato etanólico de própolis verde (nas concentrações de 2,4% e 20%) e os outros dois estudos (50%) usaram o extrato hidroalcóolico de própolis verde a 5%. Conclusão: os resultados evidenciaram que o uso tópico dos produtos formulados à base de própolis verde promoveu a cicatrização de lesões de pele, uma vez que favoreceu a angiogênese, a proliferação de fibroblastos e, consequentemente, a síntese e deposição de colágeno, bem como demonstrou atividade antimicrobiana e não apresentou toxicidade tissular, fatores esses que são considerados importantes para o processo de reparação tecidual.
Objective: To systematically identify the effectiveness of the topical use of green propolis in the healing process of surgical wounds. Methods: Systematic review of the literature that considered the publications available in the databases: National Library of Medicine(PubMed/MEDLINE), LatinAmerican and Caribbean Health Sciences Literature (LILACS), The Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Web of Science. The risk of bias of the studies was analyzed using the Systematic Review Centre for Laboratory animal Experimentation (SYRCLE) tool. Results: The four studies analyzed used green propolis for the healing of surgically made lesions. All the selected studies were of experimental methodology, performed with animals. Two studies (50%) used the ethanolic extract of green propolis (at concentrations of 2.4% and 20%) and the other two studies (50%) used the hydroalcoholic extract of green propolis at 5.0%. Conclusion: The results showed that the topical use of formulated products based on green propolis promoted the healing of skin lesions, since it favored angiogenesis, the proliferation of fibroblasts and, consequently, the synthesis and deposition of collagen, as well as showed antimicrobial activity and showed.
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