Hereditary angioedema (HAE), a rare but life-threatening condition, manifests as acute attacks of facial, laryngeal, genital, or peripheral swelling or abdominal pain secondary to intra-abdominal edema. Resulting from mutations affecting C1 esterase inhibitor (C1-INH), inhibitor of the first complement system component, attacks are not histamine-mediated and do not respond to antihistamines or corticosteroids. Low awareness and resemblance to other disorders often delay diagnosis; despite availability of C1-INH replacement in some countries, no approved, safe acute attack therapy exists in the United States. The biennial C1 Esterase Inhibitor Deficiency Workshops resulted from a European initiative for better knowledge and treatment of HAE and related diseases. This supplement contains work presented at the third workshop and expanded content toward a definitive picture of angioedema in the absence of allergy. Most notably, it includes cumulative genetic investigations; multinational laboratory diagnosis recommendations; current pathogenesis hypotheses; suggested prophylaxis and acute attack treatment, including home treatment; future treatment options; and analysis of patient subpopulations, including pediatric patients and patients whose angioedema worsened during pregnancy or hormone administration. Causes and management of acquired angioedema and a new type of angioedema with normal C1-INH are also discussed. Collaborative patient and physician efforts, crucial in rare diseases, are emphasized. This supplement seeks to raise awareness and aid diagnosis of HAE, optimize treatment for all patients, and provide a platform for further research in this rare, partially understood disorder.

No abstract

A search for neutral Higgs bosons has been performed using the full sample of Z 0 decays collected by the OPAL detector at LEP up to 1995. The data were taken at centre-of-mass energies between 88 GeV and 95 GeV and correspond to an integrated luminosity of approximately 160 pb 1. The present search addresses the processes Z 0 !H 0 Z and h 0 Z , where H 0 is the Higgs boson predicted by the Standard Model and h 0 the lightest neutral scalar Higgs boson predicted in the framework of the Minimal Supersymmetric Standard Model. For the virtual Z 0 boson, Z , the following decay c hannels are considered: Z ! , e + e and +. One candidate event

No abstract

No abstract