In a group of 48 chronic hemodialysis patients, serum levels of coenzyme Q10 (CoQ) have been measured and appeared abnormally low in 62% of cases. Figures were positively correlated to those of serum vitamin E (vit E), although the latter were within a normal range. The chronic hemodialysis (CHD) patients with normal serum values of CoQ exhibited higher blood triglycerides. Pathologically low levels of serum vit E were found only in uremic subjects on conservative regimen with dietary restrictions and low compliance to protein-caloric intake. The reduced CoQ levels may contribute to the defective serum antioxidant activity and the increased peroxidative damage in uremic patients on CHD.

Plasma antithrombin III (AT III) levels were measured as antigen concentration (radial immunodiffusion) and as heparin cofactor (amidolytic method) in 9 patients on continuous ambulatory peritoneal dialysis (CAPD). The loss of albumin, proteins, AT III antigen and AT III functional activity was calculated from the peritoneal dialysate and the corresponding serum levels were measured. The same determinations were performed on serum and urinary samples from 9 patients with nephrotic syndrome. Mean plasma levels of AT III antigen and AT III heparin cofactor in CAPD patients were normal, whereas nephrotic patients showed a reduction in these values within a wide range. However, the loss of AT III antigen was similar in both groups and was strictly correlated to the loss of albumin. Most AT III in the peritoneal dialysate from CAPD patients was still active, whereas in nephrotic patients only 26% of the excreted AT III was functionally active. The difference in plasma AT III was functionally active. The difference in plasma AT III levels between these two groups, in spite of the roughly similar amounts recovered in the dialysate and in the urine, might be explained by an additional AT III loss in nephrotic patients due to renal metabolism.

El estudio tuvo como objetivo evaluar la influencia de la Gestión de la Política Nacional de Modernización en la mejora de los procesos administrativos de la Unidad Ejecutiva 300, en la provincia de Chachapoyas, 2019. La investigación fue básica, descriptiva, no experimental. Se aplicaron 33 encuestas a trabajadores con un muestreo no probabilístico. Se utilizó como técnica la encuesta y como herramienta de investigación el cuestionario. Bajo esa metodología de investigación se demostró que los procesos administrativos de la Unidad Ejecutora 300 son ineficientes por la falta de implementación en cada uno de sus elementos, esta implementación implica un empoderamiento de su equipo directivo que delimite las funciones sustentado en la actualización de sus documentos de gestión como instrumento de línea en consecuencia se concluyó que la Política Nacional de la Modernización de la Gestión Publica influye positivamente, enfatizando que la  gestión de esta política  implica un proceso de mejora continua para que las acciones del Estado satisfagan las necesidades y expectativas de los ciudadanos.

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