Earlier work suggested that scopolamine might cause a blockade of olfactory perception. Rats were trained to perform a smell-discrimination and head-poke response for food reinforcement. Following treatment with saline or scopolamine (SeOl, rats were retested on these two tasks as well as on passive avoidance. Scopolamine significantly impaired passive avoidance and head-poke responding. Scopolamine also caused a delay in the onset of discrimination performance. There was a significant disruption of smell discrimination on early trials, during which seo rats failed to execute choices, whether correct or incorrect. However, when seo rats began to execute choices, their choices were correct. They showed a significant improvement over trials and maintained near-perfect discrimination on the second half of the test. The results of the smell-discrimination test indicate that scopolamine did not cause a complete blockade of olfactory perception. The results of the head-poke test suggest that scopolamine might increase vibrissae sensitivity.
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