The revolution of industry 4.0 becomes a new challenge to prepare the students to have high computing technology ability. This demand changes the conventional learning method using more manual tools into the one using digital-based computing ware. Interactive multimedia is a type of media operated using handheld and mobile computing ware, android-based smartphone. Interactive multimedia can display information in text, image, audio, video, and animation formats. Information can be presented real time anytime and anywhere in real environment setting. Interactive multimedia potentially makes the learning process running effectively. In addition, interactive multimedia potentially improves students' learning motivation and outcome and practices high-order thinking skills such as analytical, critical, and creative thinking skills. The use of interactive multimedia in the learning needs the synergy of technology ware availability, students' preparedness, teachers' preparedness, and school regulation, and stakeholders. The methods employed in this research were observation on learning activity and literature study referring to various relevant sources. Thus, android-based interactive multimedia is one of solutions to improve the quality of learning and to prepare the students for dealing with the competition in industrial revolution era 4.0.