Electrooxidation of dextrose on platinized platinum electrodes has been studied in phosphate buffer at pH 7.4. Rest potentials are interpreted as mixed potentials. Galvanostatic curves have been observed to exhibit oscillatory voltage behavior. In the range of potentials investigated gluconic acid is observed as the reaction product and is found to inhibit oxidation of dextrose due to adsorption on the electrode surface. From the measurements of the adsorption characteristics of the acid, the oscillatory voltage behavior of the galvanostatic curves have been ascribed to kinetic effects of formation of the product and the potential dependence of its adsorption.

Previous work with subcutaneous implants in a rat animal model has shown that pillarlike surface microstructure will reduce fibrosis and enhance blood vessel approximation to the implant surface when compared with nontextured controls. This study was designed to determine the effect of microtissue anatomy and implant site on the observed response, as well as the effect of implant fixation. The lateral posterior sites were found to contain a fat pad which produced a dramatically reduced fibrosis for the microstructured implants compared with smooth controls. Al-though significant differences between pillar-microstructured implants and controls were found for most sites, neither fascia nor muscle reduces the level of cellular response to the same degree as fat. Suture fixation of the implants did not produce a significantly different response in these tests. The occupation of the interpillar spaces by fat and moderation of interfacial shear forces is proposed as a mechanism to explain these results. 0 1996 John Wiley & Sons, Inc.

Previous work with subcutaneous implants in a rat animal model has shown that pillarlike surface microstructure will reduce fibrosis and enhance blood vessel approximation to the implant surface when compared with nontextured controls. This study was designed to determine the effect of microtissue anatomy and implant site on the observed response, as well as the effect of implant fixation. The lateral posterior sites were found to contain a fat pad which produced a dramatically reduced fibrosis for the micro-structured implants compared with smooth controls. Although significant differences between pillar-micro-structured implants and controls were found for most sites, neither fascia nor muscle reduces the level of cellular response to the same degree as fat. Suture fixation of the implants did not produce a significantly different response in these tests. The occupation of the interpillar spaces by fat and moderation of interfacial shear forces is proposed as a mechanism to explain these results.