No abstract

Cmax values for enalapril are about 10 times those published in the literature and the rate and extent of absorption of the two brands of enalapril and their deesterification to enalaprilat following the administration of either brand were bioequivalent. Secondly, enalaprilat concentrations at 12-24 h following a single oral dose of enalapril in healthy volunteers were lower than those reported in the literature. The values reported here correlated with the return of blood pressure to predose level. Thirdly, enzyme immunoassays for enalapril and enalaprilat are better than ACE inhibition assays and can be used in bioequivalence assessment of enalapril and enalaprilat and for therapeutic drug monitoring in a clinical laboratory setting.

ABSTRAKPenelitian ini bertujuan untuk mengetahui pengaruh Puasa Ramadhan terhadap kadar gula darah pada penderita diabetes di Puskesmas Kota Purwakarta Jawa Barat. Desain penelitian ini menggunakan quasi eksperimen pre and post test with control group, tehnik pengambilan sampel yang dilakukan dengan Purposive sampling dengan jumlah sampel yang 36 responden. Hasil penelitian ini menggunakan uji T-Independen puasa perbedaan kadar gula darah setelah puasa ramadhan pada kelompok kontrol dan kelompok intervensi didapatkan nilai p = 0,039 < α = 0,05. Artinya adalah hasil penelitian ini menunjukan adanya pengaruh puasa ramadhan terhadap kadar gula darah pada pasien diabetes mellitus tipe II di Puskesmas Kota Purwakarta. Demikian dapat disimpulkan bahwa manjalankan Puasa pada bulan Ramadhan dapat dijadikan sebagai metode alternatif diet yang memiliki manfaat positif jika dijalankan oleh penderita Diabetes mellitus tipe II yakni dapat menurunkan gula darah agar lebih stabil. ABSTRACTThe purpose of this research is to know the influence of Ramadan Fasting towards blood sugar levels in diabetics in the health center in West Java of Purwakarta. The design of this research uses quasi experiment of pre and post test with the control group, the method uses Purposive sampling done by the sum of 36 samples of respondents. The results of this research are using Independent T-test fast differences in blood sugar levels after fasting Ramadaan in the control group and the intervention group obtained the value of p = 0.039 < α = 0.05. Conclusion the results of this study showed the presence of the influence of fasting of Ramadan towards blood sugar levels in type II diabetes mellitus patients in Healty Center of Purwakarta. It can be concluded that fasting during Ramadan can be used as an alternative diet method that has positive benefits if it is run by type II diabetes mellitus patients which can reduce blood sugar to be more stable.

The purpose of this study was to determine the factors associated with the incidence of hypertension in the Work Area of Bonegunu Health Center, North Buton Regency. This study uses a cross sectional study analytic survey design. The results of the study using the chi-square test showed that p value = 0,000 for knowledge, p value = 0.001 for physical activity / sports, p value = 0.002 for diet, p value = 0.002 infrastructure, pvalue = 0,000 for alcohol consumption, and p value = 0,000 for stress with hypertension. Conclusion, there is a relationship between knowledge, physical activity, diet, health facilities, alcohol consumption and stress with the incidence of hypertension.   Keywords: Hypertension Occurrence Factors, Hypertension

The purpose of this study was to determine the effect of foot exercises on decreasing neuropathy scores and blood sugar levels in patients with type 2 diabetes mellitus. This study used a quasi-experimental design with the Pretest-Posttest Control Group Design approach. The sample in this study consisting of intervention group (n=16) and the control group (n=16). Measurement of neuropathy using Michigan Neuropathy Screening Instrument (MNSI). The statistical test used was the Wilcoxon test, t-dependent test, Mann-Withney test. The results of the study in the intervention group had a significant decrease in neuropathy scores and blood sugar levels (p=0.001). Whereas in the control group there was no significant decrease in neuropathy scores (p=0.069) and blood sugar levels (p=0.184). Based on the Mann-Withney test results showed that there were significant differences in neuropathy scores and blood sugar levels between the intervention group and the control group (p=0.003; p=0.042).The conclusion of this study is that patients with type 2 diabetes mellitus who are given foot gymnastic action have decreased neuropathy scores and blood sugar levels.  Keywords : Foot Exercise, Neuropathy Score, Blood Sugar Level, Michigan Neuropathy Screening Instrument (MNSI), Type 2 DM