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Background: Research using the Health Belief Model (HBM) is expected to be able to determine a determinant model of mental health behavior for Covid-19 survivors. The focus of HBM is Health Promotion at the individual level by looking at the protective and risk factors that are responsible for a person’s behavioral resistance. Until now there is no instrument that measures individual attitudes and beliefs based on the HBM for the mental health behavior of Covid-19 Survivors. Method: To assess the validity and reliability of the Health Belief Model Questionnaire for Mental Health Behavior for COVID-19 Survivors. This study is an observational study with a cross sectional approach that presents the results of the validity and reliability of the Health Belief Model Questionnaire instrument for Mental Health Behavior for COVID-19 Survivors. The questionnaire was compiled as many as 16 statement items based on a literature review. The questionnaire consists of Perceptions of Seriousness, Perceptions of Vulnerability, Perceptions of Benefits, Perceptions of Barriers with 4 question items each. The sample size is 64 people. The validity test uses the Pearson Product Moment Correlation formula with a coefficient value of 0.3, while the reliability test uses internal consistency with Cronbach’s Alpha with a coefficient value of 0.7. Results: The results of the descriptive analysis showed that the average age of Covid survivors was 18-40 years (78.1%), female (79.7%), undergraduate education level (75%), affected in wave II (54.7%) ). The results of the validity test of the 16 items contained 1 invalid item (perception of barriers), while the reliability test showed that of the 15 valid items the results were all reliable. Conclusion: Overall, the HBM questionnaire is valid and reliable to measure mental health behavior in COVID-19 survivors.

<p><strong><em>Introduction</em></strong><em>: Polycystic ovary syndrome (PCOS) is heterogeneous, complex endocrine disorder with unknown etiology, affecting 4%−18% of reproductive age women and associated with reproductive, metabolic and psychological dysfunction. Along with physical disorders, many mental disorders are also associated with PCOS, about 40% of women with PCOS have depression. This literature review aims to explore how PCOS can lead to depression in term of psychoneuroimmunology aspects.</em></p><p><strong><em>Method</em></strong><em>: Literature review was conducted through search engine from Google Scholar and Clinical Key with keywords “Polycystic ovary syndrome”, “depression”, “psychoneuroimmunology”, “distress”, and “inflammation” from 2015-2020.</em></p><p><strong><em>Result</em></strong><em>: The important role of the HPG axis in the pathophysiology of mood disorder has concluded that high comorbidity between depression and PCOS are caused by hyperandrogenism and insulin resistance mediated by low grade chronic inflammation. The activation of HPA by stress exerts an inhibitory effect on the female reproductive system. CRH can inhibit GnRH secretion from the hypothalamus. The anti-reproductive action of CRH in the ovaries of women with high psychosocial stress lead to early ovarian failure. In addition, the pathophysiology of depression and mental stress in PCOS is associated with various changes including high activity of pro-inflammation markers and the body's immune system during stress, it has also been linked to increased cortisol levels, increased sympathetic activity and decreased serotonin levels in the central nervous system.</em></p><p><strong><em>Result</em></strong><em>: There’s close relationship between PCOS and depression in terms of psychoneuroimmunology aspects, by HPG axis role. Comprehensive management of depression is improving outcome strategy in women with PCOS by involving CLP.</em></p><p><strong><em>Keywords</em></strong><em>: <strong>Polycystic ovary syndrome (PCOS), Depression, Psychoneuroimmunology, HPG axis</strong></em></p>