The development of functional materials for tumor immunogenicity
enhancement is desirable for overcoming the low therapeutic efficiency
and easy metastasis during tumor treatments. Herein, the thermoresponsive
nanoparticles composed of photothermal agent (PTA) and click reactive
reagent are developed for enhanced immunotherapy application. A Ni-bis(dithiolene)-containing
PTA with intense near-infrared absorption and efficient photothermal
conversion is developed for thermoresponsive nanoparticles construction.
The generated heat by encapsulated PTA further induces the phase transition
of thermoresponsive nanoparticles with the release of chemotherapy
reagent to react with the amino groups on functional proteins, realizing
PTT and chemotherapy simultaneously. Moreover, the immunogenic cell
death (ICD) of cancer cells evoked by PTT could be further enhanced
by the released reactive reagent. As a result, the synergistic effect
of photothermal treatment and reaction-mediated chemotherapy can suppress
the growth of a primary tumor, and the evoked ICD could further activate
the immune response with the suppression of a distant tumor. This
synergistic treatment strategy provides a reliable and promising approach
for cancer immunotherapy in clinic.
The development of functional materials for the tumor immunogenicity enhancement is desirable for overcoming the low therapeutic efficiency and easy metastasis during tumor treatments. Herein, thermos-responsive nanoparticles composed of photothermal agent (PTA) and click reactive reagent are developed for enhanced immunotherapy application. A metal-bis(dithiolene)-containing PTA with intense near-infrared (NIR) absorption and efficient photo-thermal conversion is developed for thermal-responsive nanoparticles construction. The generated heat by encapsulated PTA will further induce the phase transition of thermos-responsive nanoparticles with the release of chemotherapy reagent to react with the amino groups on functional proteins, realizing PTT and chemotherapy simultaneously. Moreover, immunogenic cell death (ICD) of cancer cells evoked by PTT will be further enhanced by the released reactive reagent. As a result, the synergistic effect of photothermal treatment and reaction-mediated chemotherapy can suppress the growth of primary tumor, and the evoked ICD will further activate the immune response with the suppression of distant tumor. This synergistic treatment strategy provides a reliable and promising approach for cancer immunotherapy in clinic.
Among the factors affecting rock mass failure, the stress state has the greatest influence on the mechanical behavior of rock. The mechanical behavior of rock depends on the change of stress path, and the stress of rock mass is closely related to deformation and failure. In order to study the influence of surrounding rock stress state on the failure mode of surrounding rock, based on the theory of elastic mechanics and fracture mechanics, this paper analyzed the stress state of surrounding rock element and crack propagation of surrounding rock, and estimated the potential failure mode of surrounding rock in different areas of a phosphate mine in Yichang. The results showed that: the surrounding rock element is affected by the gradient stress, and a larger stress gradient corresponds to a larger principal stress ratio and variation direction of the surrounding rock. The failure mode of surrounding rock is affected by the coupling effect of principal stress ratio and principal stress direction. Under the action of certain crack angle and appropriate confining pressure, different fracture mechanisms may occur in the surrounding rock compression. But the partition of surrounding rock failure mode region can predict the surrounding rock failure mode to a certain extent.
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